ArticlePeerJ2013
Hypothyroidism and diabetes mellitus - a risky dual gestational endocrinopathy.
Article in PeerJ, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- Pregnancy complications and caesarean section: a latent class analysis.Journal of global health · 2026Article
- Comparison of Factors Influencing Gestational Outcomes in Healthy Versus Hypothyroid Women from Karachi, Pakistan.Archives of Iranian medicine · 2024Article
- Prevalence and risk factors of gestational diabetes in the health region of Lleida: a retrospective observational cohort study.Journal of endocrinological investigation · 2023Observational
- The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.International journal of biological sciences · 2021Review
- Neurological manifestation in severe hypothyroidism in pregnancy.BMJ case reports · 2020Article
- Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Review
- Article
- Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats.Molecular biology reports · 2019Article
- Association of Thyroid Dysfunction and Autoimmunity in Pregnant Women with Diabetes Mellitus.Journal of obstetrics and gynaecology of India · 2018Article
- Article
- Expression and Clinical Significance of Serum 25-OH-D in pregnant women with SCH (Subclinical Hypothyroidism) and GDM (Gestational Diabetes Mellitus).Pakistan journal of medical sciencesArticle
- Prepregnancy Hypothyroidism versus Gestational Hypothyroidism: A Comparative Study.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives. Diabetes mellitus (DM) and hypothyroidism are each associated with increased rate of pregnancy complications. However, their combined morbidity during gestation is poorly studied. Therefore, the aims of this study were to determine the prevalence of the combined morbidity of DM & hypothyroidism and whether it is associated with adverse maternal and neonatal outcome. Study design. This population based retrospective cohort study included 87,213 women who had 232,293 deliveries. All deliveries were divided into the following groups: (1) hypothyroidism & DM (n = 171); (2) hypothyroidism (n = 1502); (3) DM (n = 13,324); and (4) deliveries of women with neither endocrinopathy, who served as a control group (n = 217, 296). Results. The prevalence of DM & hypothyroidism in our population was 0.17%. In comparisons to the other study groups, women with DM & hypothyroidism had higher rates of infertility (p < 0.001), preeclampsia (p < 0.001), chronic hypertension (p < 0.001), preterm birth (p < 0.001), and cesarean deliveries (p < 0.001). In Generalized Estimating Equations (GEE) model, hypothyroidism & DM was an independent risk factor for cesarean section (OR 3.46; 95% CI 2.53-4.75) and for preeclampsia (OR 1.82; 95%CI 1.16-2.84). Conclusion. The combination of DM & hypothyroidism is rare, yet it is associated with higher rate of infertility, cesarean sections, preterm deliveries, and hypertensive disorders of pregnancy than the rest of the population. This dual endocrinological combination is an independent risk factor for preeclampsia and cesarean section. These findings suggest that these patients are at risk for perinatal complications and should be followed and delivered as high risk pregnancies.
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Registered trials
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