ArticlePeerJ2013
Na(+)/Ca(2+) selectivity in the bacterial voltage-gated sodium channel NavAb.
Article in PeerJ, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- In silico analysis of sodium ion permeation mechanisms in transient receptor potential vanilloid 1.Scientific reports · 2025Article
- CaeLife · 2020Article
- Role of the Interaction Motif in Maintaining the Open Gate of an Open Sodium Channel.Biophysical journal · 2018Article
- Molecular Dynamics of Ion Conduction through the Selectivity Filter of the NaThe journal of physical chemistry. B · 2018Article
- K+ Block Is the Mechanism of Functional Asymmetry in Bacterial Na(v) Channels.PLoS computational biology · 2016Article
- Locating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channel.PLoS computational biology · 2014Article
- Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations.PLoS computational biology · 2014Article
- Effects of the protonation state of the EEEE motif of a bacterial Na(+)-channel on conduction and pore structure.Biophysical journal · 2014Article
- Investigating the size and dynamics of voltage-gated sodium channel fenestrations.Channels (Austin, Tex.) · 2014Article
- K(+) and Na(+) conduction in selective and nonselective ion channels via molecular dynamics simulations.Biophysical journal · 2013Review
- Detailed Examination of a Single Conduction Event in a Potassium Channel.The journal of physical chemistry letters · 2013Article
- Catalysis of Na+ permeation in the bacterial sodium channel Na(V)Ab.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.Biophysical journal · 2013Article
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1 author.
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Abstract
The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated. The way these channels select between Na(+) and K(+) has been investigated in computational studies, but the selectivity for Na(+) over Ca(2+) has not yet been studied in this way. Here we use molecular dynamics simulations to calculate the energetics of Na(+) and Ca(2+) transport through the channel. Single ion profiles show that Ca(2+) experiences a large barrier midway through the selectivity filter that is not seen by Na(+). This barrier is caused by the need for Ca(2+) to partly dehydrate to pass through this region and the lack of compensating interactions with the protein. Multi-ion profiles show that ions can pass each other in the channel, which is why the presence of Ca(2+) does not block Na(+) conduction despite binding more strongly in the pore.
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