ArticleClinical psychological science : a journal of the Association for Psychological Science2013
Targeted Rejection Triggers Differential Pro- and Anti-Inflammatory Gene Expression in Adolescents as a Function of Social Status.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Sexual orientation concealment and mental health: A conceptual and meta-analytic review.Psychological bulletin · 2020Pooled it
- Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.Annals of the New York Academy of Sciences · 2016Pooled it
- Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months.Development and psychopathology · 2025Article
- How community connection, homophobia, and racism shape gene expression in sexual minority men with and without HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Peer Mindset Culture as a Developmental Context for Belonging.Educational psychology review · 2025Review
- The beneficial effects of social support and prosocial behavior on immunity and health: A psychoneuroimmunology perspective.Brain, behavior, & immunity - health · 2024Article
- Understanding the Development of Chronic Loneliness in Youth.Child development perspectives · 2024Article
- Stress, Allostatic Load, and Neuroinflammation: Implications for Racial and Socioeconomic Health Disparities in Glaucoma.International journal of molecular sciences · 2024Review
- A Developmental Model of the Sexual Minority Closet: Structural Sensitization, Psychological Adaptations, and Post-closet Growth.Archives of sexual behavior · 2023Article
- Human social genomics: Concepts, mechanisms, and implications for health.Lifestyle medicine (Hoboken, N.J.) · 2023Article
- Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.Health psychology review · 2023Article
- Social Safety Theory: Understanding social stress, disease risk, resilience, and behavior during the COVID-19 pandemic and beyond.Current opinion in psychology · 2022Review
- Early Timing and Determinants of the Sexual Orientation Disparity in Internalizing Psychopathology: A Prospective Cohort Study from Ages 3 to 15.Journal of youth and adolescence · 2022Article
- Article
- The impact of stress and coping strategies on life satisfaction in a national sample of adolescents: A structural equation modelling approach.Stress and health : journal of the International Society for the Investigation of Stress · 2021Article
- Networks, cultures, and institutions: Toward a social immunology.Brain, behavior, & immunity - health · 2021Article
- Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation.Brain, behavior, & immunity - health · 2021Article
- Post-weaning Social Isolation in Male and Female Prairie Voles: Impacts on Central and Peripheral Immune System.Frontiers in behavioral neuroscience · 2021Article
- Social Safety Theory: A Biologically Based Evolutionary Perspective on Life Stress, Health, and Behavior.Annual review of clinical psychology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Social difficulties during adolescence influence life-span health. To elucidate underlying mechanisms, we examined whether a noxious social event, targeted rejection (TR), influences the signaling pathways that regulate inflammation, which is implicated in a number of health problems. For this study, 147 adolescent women at risk for developing a first episode of major depression were interviewed every 6 months for 2.5 years to assess recent TR exposure, and blood was drawn to quantify leukocyte messenger RNA (mRNA) for nuclear factor-κB (NF-κB) and inhibitor of κB (I-κB) and the inflammatory biomarkers C-reactive protein and interleukin-6. Participants had more NF-κB and I-κB mRNA at visits when TR had occurred. These shifts in inflammatory signaling were most pronounced for adolescents high in perceived social status. These findings demonstrate that social rejection upregulates inflammatory gene expression in youth at risk for depression, particularly for those high in status. If sustained, this heightened inflammatory signaling could have implications for life-span health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.