ArticleAllergy, asthma & immunology research2013
Relationships between exhaled nitric oxide and atopy profiles in children with asthma.
Article in Allergy, asthma & immunology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Application of fractional exhaled nitric oxide and nasal nitric oxide in the evaluation of asthma control.Frontiers in pediatrics · 2025Article
- Increased serum eosinophilic cationic protein in children with nonspecific chronic cough.Clinical and experimental pediatrics · 2023Article
- Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis.Advances in respiratory medicine · 2022Article
- [Correlation of fractional exhaled nitric oxide in the upper and lower airways with the level of asthma control].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Inflammation Markers and FEF25-75: A Relevant Link in Children With Asthma.Allergy, asthma & immunology research · 2016Article
- A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children.
methodsA total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized).
resultsThe geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees.
conclusionsFeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.
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