ArticleIranian journal of basic medical sciences2013
Crocin enhanced functional recovery after sciatic nerve crush injury in rats.
Article in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- Neuroprotective Effect of Natural Products on Peripheral Nerve Degeneration: A Systematic Review.Neurochemical research · 2016Pooled it
- Effect of crocetin on functional recovery in the rat model of sciatic nerve crush injury: comparison with vitamin C.Veterinary research forum : an international quarterly journal · 2026Article
- Therapeutic effects of crocin in alleviating diabetic neuropathy: a preliminary randomized triple-blind placebo-controlled trial.Journal of pharmaceutical health care and sciences · 2025Article
- Role of Herbal Medicines in the Management of Brain Injury.Advances in experimental medicine and biology · 2021Review
- RETRACTED: Ultramicronized Palmitoylethanolamide and Paracetamol, a New Association to Relieve Hyperalgesia and Pain in a Sciatic Nerve Injury Model in Rat.International journal of molecular sciences · 2020Article
- Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Role of Muscarinic Receptors in Hypoalgesia Induced by Crocin in Neuropathic Pain Rats.TheScientificWorldJournal · 2020Article
- Central HVeterinary research forum : an international quarterly journal · 2020Article
- Neuroprotective potency of some spice herbs, a literature review.Journal of traditional and complementary medicine · 2019Review
- Effect ofExperimental and therapeutic medicine · 2019Article
- Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Saudi journal of biological sciences · 2018Article
- Tissue-Engineered Regeneration of Hemisected Spinal Cord Using Human Endometrial Stem Cells, Poly ε-Caprolactone Scaffolds, and Crocin as a Neuroprotective Agent.Molecular neurobiology · 2017Article
- Guinea pigs as an animal model for sciatic nerve injury.Neural regeneration research · 2017Article
- Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in male rats.Neural regeneration research · 2017Article
- Hydroalcoholic extract of red propolis promotes functional recovery and axon repair after sciatic nerve injury in rats.Pharmaceutical biology · 2016Article
- Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat.Iranian journal of basic medical sciences · 2015Article
- Bacterial melanin promotes recovery after sciatic nerve injury in rats.Neural regeneration research · 2015Article
- Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat.Iranian journal of basic medical sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. MATERIALS AND
methodsFifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively); group 5 (sham surgery + normal saline); groups 6-9 (crush + normal saline and crush + crocin at doses of 5, 20 and 80 mg/kg, respectively). Normal saline and crocin were IP injected for 10 consecutive days after induction of a standard crush injury in left sciatic nerve. Footprints were obtained 1 day before and weekly after induction of nerve injury for evaluation of sciatic functional index (SFI). Blood samples were taken for evaluation of malondialdehyde (MDA) levels. Histopathological changes of sciatic nerve were investigated by light microscopy.
resultsSciatic nerve crush-injured rats showed SFI values reduction, increased plasma MDA levels and produced Wallerian degeneration in sciatic nerve. Crocin at a dose of 5 mg/kg had no significant effects. At doses of 20 and 80 mg/kg, crocin accelerated the SFI recovery, decreased MDA levels and reduced Wallerian degeneration severity.
conclusionThe present study suggests that the neuroprotective effects afforded by crocin may be due in part to reduction of free radicals-induced toxic effects.
Indexed as
Identifiers
23638296PMC3637908W1496548523What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.