ArticleIranian journal of basic medical sciences2013
Crocin restores hypotensive effect of subchronic administration of diazinon in rats.
Article in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 74 citations in OpenAlex.
- Potential therapeutic effects of crocin.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- An overview of pharmacological effects of Crocus sativous and its constituents.Iranian journal of basic medical sciences · 2024Review
- The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats.Current medicinal chemistry · 2024Article
- Dietary carotenoids to improve hypertension.Heliyon · 2023Review
- Tissues toxicity attenuation by vitamin E on oxidative damage induced by diazinon.Environmental analysis, health and toxicology · 2022Article
- Saffron, Its Active Components, and Their Association with DNA and Histone Modification: A Narrative Review of Current Knowledge.Nutrients · 2022Review
- Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence.Iranian journal of basic medical sciences · 2022Review
- The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2021Review
- Role of Herbal Medicines in the Management of Brain Injury.Advances in experimental medicine and biology · 2021Review
- Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Protective effect of crocin on bisphenol A - induced spatial learning and memory impairment in adult male rats: Role of oxidative stress and AMPA receptor.Iranian journal of basic medical sciences · 2020Article
- Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.Nutrients · 2020Article
- Immunoregulatory and anti-inflammatory properties ofIranian journal of basic medical sciences · 2019Review
- The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms.Iranian journal of pharmaceutical research : IJPR · 2019Article
- The Prophylactic and Therapeutic Effects of Saffron Extract and Crocin on Ethanol Withdrawal Syndrome in Mice.Journal of pharmacopuncture · 2018Article
- Pharmacokinetic Properties of Saffron and its Active Components.European journal of drug metabolism and pharmacokinetics · 2018Review
- Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress.Respiratory research · 2018Article
- Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB, BDNF, and VGF proteins in rat cerebellum.Journal of pharmacopuncture · 2018Article
- Neuroprotective potential of crocin against malathion-induced motor deficit and neurochemical alterations in rats.Environmental science and pollution research international · 2018Article
- Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice.Journal of pharmacopuncture · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): In this study, the effects of crocin against subchronic toxicity of diazinon (DZN) on systolic blood pressure (SBP) and heart rate (HR) were evaluated in rats. MATERIALS AND
methodsRats were equally divided into 7 groups; control (corn oil), DZN (15 mg/kg), crocin (each group received 12.5, 25 or 50 mg/kg crocin plus DZN), vitamin E (200 IU/kg plus DZN) and crocin (50 mg/kg) treated groups. Rats were given DZN via gavage once a day for 4 weeks. Vitamin E (three times per week) and crocin (once a day) were intraperitoneally injected to rats for 4 weeks. Plasma cholinesterase activity (Elman method), malondealdehyde (MDA) levels in the aortic tissue (Thiobarbituric acid reactive substances or TBARS method); SBP and HR (tail cuff method) were evaluated at the end of 4th week.
resultsA significant decrease in cholinesterase activity was observed in DZN group (P< 0.001). Crocin did not show any effects on cholinesterase activity. DZN increased MDA levels in aortic tissue (P< 0.001) in comparison with control group. Crocin and vitamin E plus DZN decreased MDA elevation induced by DZN in aortic tissue. DZN significantly reduced SBP (P< 0.01) and increased HR (P< 0.001) in comparison with control. Concurrent administration of crocin and DZN, improved the reduction of SBP and the elevation of HR induced by DZN in rat. Crocin alone did not have any effect on SBP and HR.
conclusionThis study showed that concurrent administration of crocin and DZN could restore the effects of subchronic DZN administration on SBP and HR in rats.
Indexed as
Identifiers
23638294PMC3637906W2108172774What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.