ArticleInternational journal of clinical and experimental pathology2013
Knocking down SMC1A inhibits growth and leads to G2/M arrest in human glioma cells.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Linking Genotype to Clinical Features inGenes · 2025Review
- Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer.Cells · 2025Article
- The synergism of SMC1A cohesin gene silencing and bevacizumab against colorectal cancer.Journal of experimental & clinical cancer research : CR · 2024Article
- Article
- miRNA-mRNA Profiling Reveals Prognostic Impact ofOncology research · 2020Article
- Knockdown of lncRNA TUG1 Enhances Radiosensitivity of Prostate Cancer via the TUG1/miR-139-5p/SMC1A Axis.OncoTargets and therapy · 2020Article
- SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties.Molecular carcinogenesis · 2019Article
- Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration.International journal of biological sciences · 2018Article
- Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.International journal of biological sciences · 2017Review
- High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome.EXCLI journal · 2017Article
- MiR-9 Promotes ApoptosisCurrent chemical genomics and translational medicine · 2017Article
- Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis.International journal of molecular sciences · 2016Article
- miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells.Aging · 2016Article
- Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer.Journal of translational medicine · 2015Article
- Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer.BMC cancer · 2015Article
- Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism.International journal of genomics · 2015Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cohesin, a multiunit complex of SMC1A, SMC3 and Rad21, associates with chromatin after mitosis and holds sister chromatids together following DNA replication. It has been reported that SMC1A is mutated in some cancer types, leading to genomic instability and abnormal cell growth. In this study, we investigated the role of SMC1A in human glioma. We found that SMC1A was expressed at abnormally high levels in human glioma tissue and in cultured U251 glioma cells. Knocking down SMC1A expression in U251 cells with SMC1A-targeted interfering RNAs inhibited cell growth and induced G2/M cell cycle arrest. Furthermore, expression of the cell cycle associated gene CCNB1IP1 was dramatically increased, whereas expression of Cyclin B1 was decreased in SMC1A-deficienct U251 cells. These results suggest that SMC1A upregulation is involved in the pathogenesis of glioma.
Indexed as
Identifiers
23638217PMC3638096W1520054717What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.