ArticlePLoS neglected tropical diseases2013
Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.Cell reports · 2024Article
- An atlas of gross and histologic lesions and immunohistochemical immunoreactivity during the temporal progression of aerosolized Lassa virus induced hemorrhagic fever in cynomolgus macaques.Frontiers in cellular and infection microbiology · 2024Article
- The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Crimean Congo Haemorrhagic Fever Virus and Lassa Virus.Applied biosafety : journal of the American Biological Safety Association · 2023Review
- Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study.The Lancet. Infectious diseases · 2021Observational
- Review
- Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques.Communications biology · 2021Article
- Detecting Pathogen Exposure During the Non-symptomatic Incubation Period Using Physiological Data: Proof of Concept in Non-human Primates.Frontiers in physiology · 2021Article
- Article
- Nosocomial Transmission of Emerging Viruses via Aerosol-Generating Medical Procedures.Viruses · 2019Review
- Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters.Viruses · 2018Article
- A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever.Science translational medicine · 2018Article
- Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development.NPJ vaccines · 2018Review
- Host Transcriptional Response to Ebola Virus Infection.Vaccines · 2017Review
- A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other Etiologies.Scientific reports · 2017Article
- In vivo Ebola virus infection leads to a strong innate response in circulating immune cells.BMC genomics · 2016Article
- Transcriptional Profiling of the Immune Response to Marburg Virus Infection.Journal of virology · 2015Article
- Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man.Future virology · 2015Article
- Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques.Journal of virology · 2015Article
- Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak.Viral immunology · 2015Article
- Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lassa virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with LASV leads to the development of hemorrhagic fever in a significant number of cases, and it is estimated that thousands die each year from the disease. Little is known about the complex immune mechanisms governing the response to LASV or the genetic determinants of susceptibility and resistance to infection. In the study presented here, we have used a whole-genome, microarray-based approach to determine the temporal host response in the peripheral blood mononuclear cells (PBMCs) of non-human primates (NHP) following aerosol exposure to LASV. Sequential sampling over the entire disease course showed that there are strong transcriptional changes of the immune response to LASV exposure, including the early induction of interferon-responsive genes and Toll-like receptor signaling pathways. However, this increase in early innate responses was coupled with a lack of pro-inflammatory cytokine response in LASV exposed NHPs. There was a distinct lack of cytokines such as IL1β and IL23α, while immunosuppressive cytokines such as IL27 and IL6 were upregulated. Comparison of IRF/STAT1-stimulated gene expression with the viral load in LASV exposed NHPs suggests that mRNA expression significantly precedes viremia, and thus might be used for early diagnostics of the disease. Our results provide a transcriptomic survey of the circulating immune response to hemorrhagic LASV exposure and provide a foundation for biomarker identification to allow clinical diagnosis of LASV infection through analysis of the host response.
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