ArticlePloS one2013
Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets.EMBO reports · 2024Article
- Identification and screening of circular RNAs during adipogenic differentiation of ovine preadipocyte by RNA-seq.Journal of animal science · 2024Article
- Peripheral Neuropathy and Decreased Locomotion of aExperimental neurobiology · 2023Article
- Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions of Adipocytes under Obesogenic Conditions.International journal of molecular sciences · 2023Article
- Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process.International journal of molecular sciences · 2023Review
- AtypicalScience advances · 2022Article
- Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.Life science alliance · 2022Article
- Identification of two pathways mediating protein targeting from ER to lipid droplets.Nature cell biology · 2022Article
- Fine-tuning cell organelle dynamics during mitosis by small GTPases.Frontiers of medicine · 2022Review
- An Integrative Analysis Identifying RAB40C as an Oncogenic Immune Protein and Prognostic Marker of Lung Squamous Cell Carcinoma.Pharmacogenomics and personalized medicine · 2022Article
- Interactions of Lipid Droplets with the Intracellular Transport Machinery.International journal of molecular sciences · 2021Review
- Article
- Methods to Study the Unique SOCS Box Domain of the Rab40 Small GTPase Subfamily.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Knockout of butyrophilin subfamily 1 member A1 (Journal of animal science and biotechnology · 2020Article
- The evolutionary landscape of the Rab family in chordates.Cellular and molecular life sciences : CMLS · 2019Article
- Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets.Molecular and cellular biology · 2019Article
- Rab18: new insights into the function of an essential protein.Cellular and molecular life sciences : CMLS · 2019Review
- Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.Small GTPases · 2018Review
- A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C.Oncotarget · 2017Article
- COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.The EMBO journal · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated in detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by neutral lipid specific dye Oil red or Nile red, but not with the Golgi or endosomal markers. Further examination demonstrated that Rab40c is also associated with ERGIC-53 containing structures, especially under the serum starvation condition. Rab40c is increasingly recruited to the surface of lipid droplets during lipid droplets formation and maturation in HepG2 cells. Rab40c knockdown moderately decreases the size of lipid droplets, suggesting that Rab40c is involved in the biogenesis of lipid droplets. Stimulation for adipocyte differentiation increases the expression of Rab40c in 3T3-L1 cells. Rab40c interacts with TIP47, and is appositionally associated with TIP47-labeled lipid droplets. In addition, over-expression of Rab40c causes the clustering of lipid droplets independent of its GTPase activity, but completely dependent of the intact SOCS box domain of Rab40c. In addition, Rab40c displayed self-interaction as well as interaction with TIP47 and the SOCS box is essential for its ability to induce clustering of lipid droplets. Our results suggest that Rab40c is a novel Rab protein associated with lipid droplets, and is likely involved in modulating the biogenesis of lipid droplets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.