ArticlePloS one2013
A prospective study of LINE-1DNA methylation and development of adiposity in school-age children.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Role of DNA Methylation in Ischemic Stroke: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Epigenetics and human obesity.International journal of obesity (2005) · 2015Pooled it
- LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity.Redox report : communications in free radical research · 2016Trial
- Epigenetics and childhood obesity: DNA methylation coordinates environment and gene regulation.Endocrine reviews · 2026Review
- Changes in methylation associated with development of metabolic syndrome in testicular cancer patients treated with cisplatin chemotherapy.Scientific reports · 2025Article
- DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents.Epigenomes · 2023Article
- Maternal blood glucose level and offspring glucose-insulin homeostasis: what is the role of offspring adiposity?Diabetologia · 2021Article
- The Relationship between Body Mass Index, Obesity, and LINE-1 Methylation: A Cross-Sectional Study on Women from Southern Italy.Disease markers · 2021Article
- Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age.International journal of molecular sciences · 2020Article
- In utero exposure to gestational diabetes mellitus and cardiovascular risk factors in youth: A longitudinal analysis in the EPOCH cohort.Pediatric obesity · 2020Article
- A prospective study of associations between in utero exposure to gestational diabetes mellitus and metabolomic profiles during late childhood and adolescence.Diabetologia · 2020Article
- DNA methylation markers in obesity, metabolic syndrome, and weight loss.Epigenetics · 2019Review
- Article
- Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression.Epigenetics · 2018Article
- INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.Molecular medicine reports · 2018Article
- The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease.Global challenges (Hoboken, NJ) · 2017Review
- Epigenetics, obesity and early-life cadmium or lead exposure.Epigenomics · 2017Review
- Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children.Environmental research · 2016Article
- DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery.Obesity surgery · 2016Article
- Examination of Global Methylation and Targeted Imprinted Genes in Prader-Willi Syndrome.Journal of clinical epigenetics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRepetitive element DNA methylation is related to prominent obesity-related chronic diseases including cancer and cardiovascular disease; yet, little is known of its relation with weight status. We examined associations of LINE-1 DNA methylation with changes in adiposity and linear growth in a longitudinal study of school-age children from Bogotá, Colombia.
methodsWe quantified methylation of LINE-1 elements from peripheral leukocytes of 553 children aged 5-12 years at baseline using pyrosequencing technology. Anthropometric characteristics were measured periodically for a median of 30 months. We estimated mean change in three age-and sex-standardized indicators of adiposity: body mass index (BMI)-for-age Z-score, waist circumference Z-score, and subscapular-to-triceps skinfold thickness ratio Z-score according to quartiles of LINE-1 methylation using mixed effects regression models. We also examined associations with height-for-age Z-score.
resultsThere were non-linear, inverse relations of LINE-1 methylation with BMI-for-age Z-score and the skinfold thickness ratio Z-score. After adjustment for baseline age and socioeconomic status, boys in the lowest quartile of LINE-1 methylation experienced annual gains in BMI-for-age Z-score and skinfold thickness ratio Z-score that were 0.06 Z/year (P = 0.04) and 0.07 Z/year (P = 0.03), respectively, higher than those in the upper three quartiles. The relation of LINE-1 methylation and annual change in waist circumference followed a decreasing monotonic trend across the four quartiles (P trend = 0.02). DNA methylation was not related to any of the adiposity indicators in girls. There were no associations between LINE-1 methylation and linear growth in either sex.
conclusionsLower LINE-1 DNA methylation is related to development of adiposity in boys.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.