ArticlePloS one2013
A novel injectable calcium phosphate cement-bioactive glass composite for bone regeneration.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Critical appraisal of bone graft meta-analysis in tibial plateau fractures.World journal of orthopedics · 2026Article
- Enhanced Osteogenic and Neurogenic Differentiation of Dental Pulp Stem Cells by Micro-Current Stimulation and Chitosan-Poly(Ethylene Glycol) Blended Calcium Phosphate Cement.ACS applied bio materials · 2026Article
- Synergistic effects of bioactive glass and sodium alginate on the surface properties and therapeutic release of ciprofloxacin from apatite cements.International journal of pharmaceutics: X · 2025Article
- Current and Future Perspectives of Bioactive Glasses as Injectable Material.Nanomaterials (Basel, Switzerland) · 2024Review
- Regulation of the antibiotic elution profile from tricalcium phosphate bone cement by addition of bioactive glass.Scientific reports · 2024Article
- Materials in the NaMaterials (Basel, Switzerland) · 2023Review
- Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?Bioactive materials · 2023Review
- The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement.Nanomaterials (Basel, Switzerland) · 2021Article
- Biosynthesis of Bonelike Apatite 2D Nanoplate Structures Using Fenugreek Seed Extract.Nanomaterials (Basel, Switzerland) · 2020Article
- Development and Characterization of Composites Consisting of Calcium Phosphate Cements and Mesoporous Bioactive Glass for Extrusion-Based Fabrication.Materials (Basel, Switzerland) · 2019Article
- Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors.Biomaterials science · 2018Article
- Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation.Scientific reports · 2017Article
- Article
- The biocompatibility of calcium phosphate cements containing alendronate-loaded PLGA microparticles in vitro.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Tissue engineering for bone regeneration and osseointegration in the oral cavity.Dental materials : official publication of the Academy of Dental Materials · 2015Review
- The synergistic effects of Chinese herb and injectable calcium silicate/β-tricalcium phosphate composite on an osteogenic accelerator in vitro.Journal of materials science. Materials in medicine · 2015Article
- A novel two-step sintering for nano-hydroxyapatite scaffolds for bone tissue engineering.Scientific reports · 2014Article
- Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration.Journal of dental research · 2014Review
- Scaffold design for bone regeneration.Journal of nanoscience and nanotechnology · 2014Review
- Self-setting calcium orthophosphate formulations.Journal of functional biomaterials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium phosphate cement (CPC) can be molded or injected to form a scaffold in situ, which intimately conforms to complex bone defects. Bioactive glass (BG) is known for its unique ability to bond to living bone and promote bone growth. However, it was not until recently that literature was available regarding CPC-BG applied as an injectable graft. In this paper, we reported a novel injectable CPC-BG composite with improved properties caused by the incorporation of BG into CPC. MATERIALS AND
methodsThe novel injectable bioactive cement was evaluated to determine its composition, microstructure, setting time, injectability, compressive strength and behavior in a simulated body fluid (SBF). The in vitro cellular responses of osteoblasts and in vivo tissue responses after the implantation of CPC-BG in femoral condyle defects of rabbits were also investigated.
resultsCPC-BG possessed a retarded setting time and markedly better injectability and mechanical properties than CPC. Moreover, a new Ca-deficient apatite layer was deposited on the composite surface after immersing immersion in SBF for 7 days. CPC-BG samples showed significantly improved degradability and bioactivity compared to CPC in simulated body fluid (SBF). In addition, the degrees of cell attachment, proliferation and differentiation on CPC-BG were higher than those on CPC. Macroscopic evaluation, histological evaluation, and micro-computed tomography (micro-CT) analysis showed that CPC-BG enhanced the efficiency of new bone formation in comparison with CPC.
conclusionsA novel CPC-BG composite has been synthesized with improved properties exhibiting promising prospects for bone regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.