ArticlePloS one2013
Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience.Molecular neurobiology · 2025Review
- Maternal suboptimal selenium intake and low-level lead exposure affect offspring's microglial immune profile and its reactivity to a subsequent inflammatory hit.Scientific reports · 2023Article
- Neurotoxicology of metals and metallic nanoparticles inAdvances in neurotoxicology · 2023Article
- Trévo abrogates Lead Acetate Neurotoxicity in Male Wistar Rats viz Antiamyloidogenesis, Antiglutaminergic, and Anticholinesterase Activities.Annals of neurosciences · 2022Article
- The intertwining between lead and ethanol in the model organismFrontiers in toxicology · 2022Review
- Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity.Toxics · 2021Review
- Harnessing the potential of cross-protection stressor interactions for conservation: a review.Conservation physiology · 2021Article
- Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish.International journal of molecular sciences · 2020Article
- Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.Molecular nutrition & food research · 2019Article
- C. elegans as a model in developmental neurotoxicology.Toxicology and applied pharmacology · 2018Review
- Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios.Environmental science & technology · 2016Article
- The Level of Selenium and Oxidative Stress in Workers Chronically Exposed to Lead.Biological trace element research · 2016Article
- Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study.Scientific reports · 2015Article
- Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans.PloS one · 2014Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. PRINCIPAL
findingsThe results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity.
conclusionsOur study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.
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