ArticlePloS one2013
Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Periodontitis and inflammatory bowel disease: a meta-analysis.BMC oral health · 2020Pooled it
- Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis.BMC pulmonary medicine · 2019Pooled it
- Metabolite 4-hydroxybenzoic acid, modulated by cigarette smoke exposure, functions as a protective factor in dextran sodium sulfate-induced colitis.Journal of gastroenterology · 2026Article
- Effect and Mechanisms of Electroacupuncture on Mucosal Healing in Ulcerative Colitis Mice via Non-neuroronal Cholinergic System.Chinese journal of integrative medicine · 2026Article
- Chronic Exposure to Both Electronic and Conventional Cigarettes Alters Ileum and Colon Turnover, Immune Function, and Barrier Integrity in Mice.Journal of xenobiotics · 2024Article
- An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease.Nutrients · 2023Review
- Immunoregulatory effects of RGMb in gut inflammation.Frontiers in immunology · 2022Article
- 5-Aminolevulinic Acid as a Novel Therapeutic for Inflammatory Bowel Disease.Biomedicines · 2021Article
- Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.Molecular metabolism · 2020Article
- Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues.Nutrients · 2020Article
- The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts.Scientific reports · 2020Article
- Review
- The interaction between invariant Natural Killer T cells and the mucosal microbiota.Immunology · 2018Review
- Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification.International journal of molecular sciences · 2018Review
- Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.Particle and fibre toxicology · 2017Article
- Review
- Cigarette Smoking Triggers Colitis by IFN-γFrontiers in immunology · 2017Article
- The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice.PloS one · 2015Article
- Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.International journal of molecular medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoke (CS) protects against intestinal inflammation during ulcerative colitis. Immunoregulatory mechanisms sustaining this effect remain unknown. The aim of this study was to assess the effects of CS on experimental colitis and to characterize the intestinal inflammatory response at the cellular and molecular levels. Using the InExpose® System, a smoking device accurately reproducing human smoking habit, we pre-exposed C57BL/6 mice for 2 weeks to CS, and then we induced colitis by administration of dextran sodium sulfate (DSS). This system allowed us to demonstrate that CS exposure improved colonic inflammation (significant decrease in clinical score, body weight loss and weight/length colonic ratio). This improvement was associated with a significant decrease in colonic proinflammatory Th1/Th17 cytokine expression, as compared to unexposed mice (TNF (p=0.0169), IFNγ (p<0.0001), and IL-17 (p=0.0008)). Smoke exposure also induced an increased expression of IL-10 mRNA (p=0.0035) and a marked recruitment of iNKT (invariant Natural Killer T; CD45+ TCRβ+ CD1d tetramer+) cells in the colon of DSS-untreated mice. Demonstration of the role of iNKT cells in CS-dependent colitis improvement was performed using two different strains of NKT cells deficient mice. Indeed, in Jα18KO and CD1dKO animals, CS exposure failed to induce significant regulation of DSS-induced colitis both at the clinical and molecular levels. Thus, our study demonstrates that iNKT cells are pivotal actors in the CS-dependent protection of the colon. These results highlight the role of intestinal iNKT lymphocytes and their responsiveness to environmental stimuli. Targeting iNKT cells would represent a new therapeutic way for inflammatory bowel diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.