ArticlePloS one2013
Microsporidia and its relation to Crohn's disease. A retrospective study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Dysregulated IL-7/IL-7R-CD132 Axis and Intestinal Microsporidiosis in Crohn's Disease.Pathogens (Basel, Switzerland) · 2026Article
- Draft assemblies for three geographically distinct isolates of the human-infecting microsporidiumMicrobiology resource announcements · 2025Article
- Prevalence of Anti-Pathogens (Basel, Switzerland) · 2025Article
- Article
- Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease.World journal of gastroenterology · 2025Article
- Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy.Mycopathologia · 2025Article
- Microsporidia in Commercially Harvested Marine Fish: A Potential Health Risk for Consumers.Animals : an open access journal from MDPI · 2023Article
- High Prevalence of Microsporidia in the North African Hedgehog (Animals : an open access journal from MDPI · 2023Article
- Molecular Detection of Microsporidia in Rabbits (Biology · 2022Article
- Article
- Microsporidia as a Potential Threat to the Iberian Lynx (Animals : an open access journal from MDPI · 2022Article
- Human microsporidian pathogenJournal of cell science · 2021Article
- Article
- Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis.Digestive diseases and sciences · 2018Article
- The first study on opportunistic intestinal microsporidiosis in IBD patients receiving immunosuppressive medications in Iran.Epidemiology and infection · 2017Article
- Determination of Anti-Anisakis Simplex Antibodies and Relationship with αβ and γδ Lymphocyte Subpopulations in Patients with Crohn's Disease.Digestive diseases and sciences · 2017Article
- Intestinal Barrier Interactions with Specialized CD8 T Cells.Frontiers in immunology · 2017Review
- Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19(+) cells in Crohn's disease.World journal of gastroenterology · 2015Observational
- Microbial Population Differentials between Mucosal and Submucosal Intestinal Tissues in Advanced Crohn's Disease of the Ileum.PloS one · 2015Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cause of Crohn's Disease (CD) remains unknown. Recently a decrease in the global lymphocyte population in the peripheral blood of CD patients has been reported. This decrease was more evident in γδ T lymphocytes, especially γδ CD8+T subsets. Furthermore, a decrease of IL-7 was also observed in these patients. We propose the hypothesis that microsporidia, an obligate intracellular opportunistic parasite recently related to fungi, in CD patients can take advantage of the lymphocytes and IL-7 deficits to proliferate and to contribute to the pathophysiology of this disease. METHODS AND
findingsIn this case-control study, serum samples were collected from 36 CD patients and from 36 healthy individuals (controls), IgE and IgG anti-Encephalitozoon antibodies were determined by ELISA; and forty-four intestinal tissue samples were analyzed through real time Polymerase Chain Reaction (PCR), twenty CD patients, nine with others diseases and 15 healthy subjects. We observed that IgE anti-Encephalitozoon levels were significantly higher in patients with CD: 0.386(±0.256) vs control group, 0.201(±0.147), P<0.001. However, IgG anti-Encephalitozoon values were significantly lower in CD patients: 0.361(±0.256) vs control group, 0.876(±0.380), P<0.001. In the group of CD patients, 6/20 (30%) were positive by real time PCR for microsporidia and, all the patients of the control group were negative by real time PCR.
conclusionsThese results suggest that CD patients are a group at risk for microsporidiasis and, moreover that microsporidia may be involved as a possible etiologic factor of CD.
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