ArticlePloS one2013
Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level.Nature communications · 2024Article
- Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy.Molecular neurobiology · 2024Article
- Targeted suppression of mTORC2 reduces seizures across models of epilepsy.Nature communications · 2023Article
- Towards translational optogenetics.Nature biomedical engineering · 2023Review
- In vivo inhibition of epileptiform afterdischarges in rat hippocampus by light-activated chloride channel, stGtACR2.CNS neuroscience & therapeutics · 2023Article
- LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.eNeuro · 2023Article
- Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.Scientific reports · 2023Article
- Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.Cell reports · 2021Article
- Application of Optogenetics in Epilepsy Research.Advances in experimental medicine and biology · 2021Article
- Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.Epilepsy research · 2020Article
- An Optogenetic Kindling Model of Neocortical Epilepsy.Scientific reports · 2019Article
- Novel Optogenetic Approaches in Epilepsy Research.Frontiers in neuroscience · 2019Review
- Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research.Frontiers in cellular neuroscience · 2018Review
- Optogenetics: the new molecular approach to control functions of neural cells in epilepsy, depression and tumors of the central nervous system.American journal of cancer research · 2018Review
- Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis.Journal of biomedical science · 2017Review
- Optogenetic study of networks in epilepsy.Journal of neuroscience research · 2017Review
- Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice.Molecular brain · 2017Article
- Investigation of Seizure-Susceptibility in aGenetics · 2017Article
- Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017Article
- Photolysis of Caged-GABA Rapidly Terminates SeizuresFrontiers in neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a devastating disease, currently treated with medications, surgery or electrical stimulation. None of these approaches is totally effective and our ability to control seizures remains limited and complicated by frequent side effects. The emerging revolutionary technique of optogenetics enables manipulation of the activity of specific neuronal populations in vivo with exquisite spatiotemporal resolution using light. We used optogenetic approaches to test the role of hippocampal excitatory neurons in the lithium-pilocarpine model of acute elicited seizures in awake behaving rats. Hippocampal pyramidal neurons were transduced in vivo with a virus carrying an enhanced halorhodopsin (eNpHR), a yellow light activated chloride pump, and acute seizure progression was then monitored behaviorally and electrophysiologically in the presence and absence of illumination delivered via an optical fiber. Inhibition of those neurons with illumination prior to seizure onset significantly delayed electrographic and behavioral initiation of status epilepticus, and altered the dynamics of ictal activity development. These results reveal an essential role of hippocampal excitatory neurons in this model of ictogenesis and illustrate the power of optogenetic approaches for elucidation of seizure mechanisms. This early success in controlling seizures also suggests future therapeutic avenues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.