ArticlePloS one2013
Genetic variation in the HN and SH genes of mumps viruses: a comparison of strains from mumps cases with and without neurological symptoms.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Lineage Diversification and Evolutionary Dynamics of theMicroorganisms · 2026Article
- Genetic analysis of the SH gene of mumps virus genotype C in Kerala during 2024-25.Virus genes · 2026Article
- Development and characterization of the genotype F attenuated mumps candidate strains.Frontiers in immunology · 2025Article
- Genetic characteristic of mumps virus from 2012 to 2016 and its serum antibody level among general healthy population during 2018-2020 in Jiangsu Province, China.BMC infectious diseases · 2024Article
- Booster doses of an inactivated F genotype mumps vaccine enhance immunogenicity in mice.Vaccine: X · 2024Article
- Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia.Viruses · 2023Article
- Exploring the Mumps Virus Glycoproteins: A Review.Viruses · 2022Review
- Functional Characterization of Circulating Mumps Viruses with Stop Codon Mutations in the Small Hydrophobic Protein.mSphere · 2020Article
- Mumps: MMR vaccination and genetic diversity of mumps virus, 2007-2011 in Catalonia, Spain.BMC infectious diseases · 2019Article
- Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany.International journal of environmental research and public health · 2018Review
- Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis.Medicine · 2016Observational
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is known that mumps virus (MuV) strains may vary in their neurovirulent capacity, and certain MuV strains may be highly neurotropic. In animal models and epidemiological studies, mutations at specific amino acids (aa) have been proposed to be associated with neurovirulence. To assess whether these genetic variations can be observed in clinical samples from patients and if they correlate with neurovirulence as determined by clinical symptoms, 39 mumps patients with or without neurological symptoms were investigated. PRINCIPAL
findingsRespiratory samples, oral fluids, throat swabs, and neurological and cerebrospinal fluid samples were tested by RT-PCR and products sequenced. Sequences of the entire small hydrophobic (SH) gene and the partial hemagglutinin-neuraminidase (HN) gene were compared.
conclusionsThe results showed there was no significant difference between the samples of the two groups of patients at the aa sites in either the HN protein or the SH protein, which have previously been hypothesized to be associated with neurovirulence or antigenicity. The occurrence of neurological symptoms of mumps does not appear to be due to a single point mutation in either the HN or SH gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.