ArticlePloS one2013
A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
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- A Near-Optimal Control Method for Stochastic Boolean Networks.Letters in biomathematics · 2020Article
- Reaction Systems and Synchronous Digital Circuits.Molecules (Basel, Switzerland) · 2019Article
- Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K.PLoS computational biology · 2019Article
- Attractor - a new turning point in drug discovery.Drug design, development and therapy · 2019Review
- ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming.Scientific reports · 2018Article
- Boolean network modeling in systems pharmacology.Journal of pharmacokinetics and pharmacodynamics · 2018Review
- BioLQM: A Java Toolkit for the Manipulation and Conversion of Logical Qualitative Models of Biological Networks.Frontiers in physiology · 2018Article
- HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibodyOncotarget · 2017Article
- Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.Frontiers in veterinary science · 2017Review
- An anti-HER2 antibody conjugated with monomethyl auristatin E is highly effective in HER2-positive human gastric cancer.Cancer biology & therapy · 2016Article
- Estimating Propensity Parameters Using Google PageRank and Genetic Algorithms.Frontiers in neuroscience · 2016Article
- Logical Modeling and Dynamical Analysis of Cellular Networks.Frontiers in genetics · 2016Review
- Molecular network control through boolean canalization.EURASIP journal on bioinformatics & systems biology · 2015Article
- Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.World journal of clinical oncology · 2014Review
- A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.The Journal of biological chemistry · 2014Article
- Sensitivity analysis of biological Boolean networks using information fusion based on nonadditive set functions.BMC systems biology · 2014Article
- Steady state analysis of Boolean molecular network models via model reduction and computational algebra.BMC bioinformatics · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling and their combined dysregulation plays key roles in human cancers, including breast cancer. In part due to the complexity of the biochemical network associated with the regulation of these proteins as well as their cellular functions, the role of Src in EGFR regulation remains unclear. Herein we present a new comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells. This model, constructed manually from published biochemical literature, consists of 245 nodes representing proteins and their post-translational modifications sites, and over 1,000 biochemical interactions. Using computer simulations of the model, we find it is able to reproduce a number of cellular phenomena. Furthermore, the model predicts that overexpression of Src results in increased endocytosis of EGFR in the absence/low amount of the epidermal growth factor (EGF). Our subsequent laboratory experiments also suggest increased internalization of EGFR upon Src overexpression under EGF-deprived conditions, further supporting this model-generated hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.