ArticlePloS one2013
Genetic, functional and molecular features of glucocorticoid receptor binding.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- The Bidirectional Interaction Between NF-Journal of immunology research · 2025Review
- Genotype × environment interactions in gene regulation and complex traits.Nature genetics · 2024Review
- Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Targeting the Glucocorticoid Receptors During Alcohol Withdrawal to Reduce Protracted Neurocognitive Disorders.Frontiers in psychiatry · 2019Review
- Facilitating Analysis of Publicly Available ChIP-Seq Data for Integrative Studies.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019Article
- Rosiglitazone, a Ligand to PPARPPAR research · 2019Article
- Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.Molecular cell · 2017Article
- Genomic effects of glucocorticoids.Protoplasma · 2017Review
- A prior-based integrative framework for functional transcriptional regulatory network inference.Nucleic acids research · 2017Article
- High-throughput allele-specific expression across 250 environmental conditions.Genome research · 2016Article
- A high-throughput RNA-seq approach to profile transcriptional responses.Scientific reports · 2015Article
- Article
- A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel disease, and certain types of cancer. GCs act mainly by activating the GC receptor (GR), which interacts with other transcription factors to regulate gene expression. Here, we combined different functional genomics approaches to gain molecular insights into the mechanisms of action of GC. By profiling the transcriptional response to GC over time in 4 Yoruba (YRI) and 4 Tuscans (TSI) lymphoblastoid cell lines (LCLs), we suggest that the transcriptional response to GC is variable not only in time, but also in direction (positive or negative) depending on the presence of specific interacting transcription factors. Accordingly, when we performed ChIP-seq for GR and NF-κB in two YRI LCLs treated with GC or with vehicle control, we observed that features of GR binding sites differ for up- and down-regulated genes. Finally, we show that eQTLs that affect expression patterns only in the presence of GC are 1.9-fold more likely to occur in GR binding sites, compared to eQTLs that affect expression only in its absence. Our results indicate that genetic variation at GR and interacting transcription factors binding sites influences variability in gene expression, and attest to the power of combining different functional genomic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.