ArticlePloS one2013
Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03434457 (Maternal Adversity, Vulnerability and Neurodevelopment), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Adversity, Vulnerability and Neurodevelopment
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Biological and psychosocial predictors of postpartum depression: systematic review and call for integration.Annual review of clinical psychology · 2015Pooled it
- Integrating NRG1 and OXT Polymorphisms, Maternal Psychological Vulnerability, and Obstetric-Neonatal Outcomes: A Genotype-Phenotype Pilot Study.Journal of clinical medicine · 2026Article
- Perinatal Depression: Current Knowledge.Advances in experimental medicine and biology · 2026Review
- Genetic Variants in Oxytocinergic System Genes and Their Association with Postpartum Depression Susceptibility.International journal of molecular sciences · 2025Article
- Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity.Comprehensive psychoneuroendocrinology · 2024Article
- Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
- Intertwined associations between oxytocin, immune system and major depressive disorder.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Review
- Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions.Molecular neurobiology · 2023Review
- Postpartum depression: aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring.Behavioural brain research · 2023Article
- Genomic analysis of arginine vasopressin gene in riverine buffalo reveals its potential association with silent estrus behavior.Molecular biology reports · 2022Article
- The relationship between oxytocin levels with empathy and breastfeeding intention in female medical students: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Immunological and other biological correlates of the impact of antenatal depression on the mother-infant relationship.Brain, behavior, & immunity - health · 2022Article
- Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From theFrontiers in human neuroscience · 2022Article
- Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads.Translational psychiatry · 2021Article
- Empathy and Hormonal Changes as Predictors of Sensitive Responsiveness towards Infant Crying: A Study Protocol.International journal of environmental research and public health · 2021Article
- The role of interindividual licking received and dopamine genotype on later-life licking provisioning in female rat offspring.Brain and behavior · 2021Article
- The etiology of maternal postpartum depressive symptoms: Childhood emotional maltreatment, couple relationship satisfaction, and genes.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2021Article
- Postpartum Depression: Current Status and Possible Identification Using Biomarkers.Frontiers in psychiatry · 2021Review
- AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level.Heliyon · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Individual differences in maternal behavior are affected by both early life experiences and oxytocin, but little is known about genetic variation in oxytocin genes and its effects on mothering. We examined two polymorphisms in the oxytocin peptide gene OXT (rs2740210 and rs4813627) and one polymorphism in the oxytocin receptor gene OXTR (rs237885) in 187 Caucasian mothers at six months postpartum. For OXT, both rs2740210 and rs4813627 significantly associated with maternal vocalizing to the infant. These polymorphisms also interacted with the quality of care mothers experienced in early life, to predict variation in maternal instrumental care and postpartum depression. However, postpartum depression did not mediate the gene-environment effects of the OXT SNPs on instrumental care. In contrast, the OXTR SNP rs237885 did not associate with maternal behavior, but it did associate with pre-natal (but not post-natal) depression score. The findings illustrate the importance of variation in oxytocin genes, both alone and in interaction with early environment, as predictors of individual differences in human mothering. Furthermore, depression does not appear to have a causal role on the variation we report in instrumental care. This suggests that variation in instrumental care varies in association with a gene-early environment effect regardless of current depressive symptomatology. Finally, our findings highlight the importance of examining multiple dimensions of human maternal behavior in studies of genetic associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.