ArticlePloS one2013
Physical deconditioning as a cause of breathlessness among obese adolescents with a diagnosis of asthma.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Exercise-induced symptoms in young childhood cancer survivors.Journal of cancer survivorship : research and practice · 2025Article
- Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides.ESC heart failure · 2025Article
- Exercise-Induced Bronchoconstriction in Children: State of the Art from Diagnosis to Treatment.Journal of clinical medicine · 2024Review
- Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022Review
- Impact of Increased Step Count on Adult Asthmatic Patients: A Pilot Study.PRiMER (Leawood, Kan.) · 2022Article
- Low fitness and increased sedentary time are associated with worse asthma-The National Youth Fitness Survey.Pediatric pulmonology · 2020Article
- Physical Activity: A Missing Link in Asthma Care.Journal of clinical medicine · 2020Review
- Plasma antioxidants and oxidative stress status in obese women: correlation with cardiopulmonary response.PeerJ · 2020Article
- Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management.Expert review of endocrinology & metabolism · 2019Review
- Obesity, Asthma, and Exercise in Child and Adolescent Health.Pediatric exercise science · 2016Article
- Cardiopulmonary Exercise Testing in Children and Adolescents with High Body Mass Index.Pediatric exercise science · 2016Article
- The allergy epidemics: 1870-2010.The Journal of allergy and clinical immunology · 2015Review
- Severe asthma in school-age children: evaluation and phenotypic advances.Current allergy and asthma reports · 2015Review
- Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObese children frequently complain of breathlessness. Asthma and obesity can both contribute to the symptoms during exercise, and this symptom can contribute to a diagnosis of asthma in these children. Despite the high prevalence of obesity few studies have investigated the cardiopulmonary physiology of breathlessness in obese children with a diagnosis of asthma.
methodsIn this case-control study, thirty adolescents between age 12 and 19 were studied with baseline spirometry and a cardiopulmonary exercise test. Ten adolescents were normal controls, ten had obesity without a diagnosis of asthma, and ten had obesity with a history of physician-diagnosed asthma.
resultsBaseline characteristics including complete blood count and spirometry were comparable between obese adolescents with and without a diagnosis of asthma. During exercise, obese asthmatic and obese non-asthmatic adolescents had significantly reduced physical fitness compared to healthy controls as evidenced by decreased peak oxygen uptake after adjusting for actual body weight (21.7 ± 4.5 vs. 21.4 ± 5.4 vs. 35.3 ± 5.8 ml/kg/min, respectively). However, pulmonary capacity at the peak of exercise was comparable among all three groups as evidenced by similar pulmonary reserve.
conclusionIn this study, breathlessness was primarily due to cardiopulmonary deconditioning in the majority of obese adolescents with or without a diagnosis of asthma.
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