ArticleFrontiers in neurology2013
The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care.
Article in Frontiers in neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Aptamer-based proteomics in pediatric patients with severe traumatic brain injury: a pilot study.Pediatric research · 2026Article
- Advances in biomarkers for predicting outcomes in pediatric neurosurgical hemorrhagic conditions: a narrative review to enhance quality of care.Annals of medicine and surgery (2012) · 2026Review
- Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Evaluation of neurovascular coupling during neuroprotective therapies: A single site HEAL ancillary study.Early human development · 2023Article
- Abusive Head Trauma Animal Models: Focus on Biomarkers.International journal of molecular sciences · 2023Review
- Pediatric Traumatic Brain Injury: An Update on Preclinical Models, Clinical Biomarkers, and the Implications of Cerebrovascular Dysfunction.Journal of central nervous system disease · 2022Review
- Unravelling neuroinflammation in abusive head trauma with radiotracer imaging.Pediatric radiology · 2021Review
- Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.Journal of neurotrauma · 2021Review
- Patterns of Osteopontin Expression in Abusive Head Trauma Compared with Other Causes of Pediatric Traumatic Brain Injury.The Journal of pediatrics · 2020Article
- Retinal and visual function in infants with non-accidental trauma and retinal hemorrhages.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Neurological Monitoring and Complications of Pediatric Extracorporeal Membrane Oxygenation Support.Pediatric neurology · 2020Review
- Brain metabolism and severe pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome.Korean journal of pediatrics · 2017Article
- Meta-analysis of neuron specific enolase in predicting pediatric brain injury outcomes.EXCLI journal · 2017Article
- Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.Resuscitation · 2016Article
- Increased cerebrospinal fluid cleaved tau protein (C-tau) levels suggest axonal damage in pediatric patients with brain tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Observational
- Chapter 6 state of the science of pediatric traumatic brain injury: biomarkers and gene association studies.Annual review of nursing research · 2015Review
- Perinatal biomarkers in prematurity: early identification of neurologic injury.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Review
- Microwave & Magnetic (MTranslational proteomics · 2014Article
- Post-acute brain injury urinary signature: a new resource for molecular diagnostics.Journal of neurotrauma · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The use of biomarkers of brain injury in pediatric neurocritical care has been explored for at least 15 years. Two general lines of research on biomarkers in pediatric brain injury have been pursued: (1) studies of "bio-mediators" in cerebrospinal fluid (CSF) of children after traumatic brain injury (TBI) to explore the components of the secondary injury cascades in an attempt to identify potential therapeutic targets and (2) studies of the release of structural proteins into the CSF, serum, or urine in order to diagnose, monitor, and/or prognosticate in patients with TBI or other pediatric neurocritical care conditions. Unique age-related differences in brain biology, disease processes, and clinical applications mandate the development and testing of brain injury bio-mediators and biomarkers specifically in pediatric neurocritical care applications. Finally, although much of the early work on biomarkers of brain injury in pediatrics has focused on TBI, new applications are emerging across a wide range of conditions specifically for pediatric neurocritical care including abusive head trauma, cardiopulmonary arrest, septic shock, extracorporeal membrane oxygenation, hydrocephalus, and cardiac surgery. The potential scope of the utility of biomarkers in pediatric neurocritical care is thus also discussed.
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