Evidence map›Paper›PMID 23637623›Full record

ArticlePLoS genetics2013

Signatures of diversifying selection in European pig breeds.

Samantha Wilkinson, Zen H Lu, Hendrik-Jan Megens, Alan L Archibald, Chris Haley, Ian J Jackson, Martien A M Groenen, Richard P M A Crooijmans, Rob Ogden, Pamela Wiener

Open access · goldAbstract read
In one paragraph

Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Gene Editing for Enhanced Swine Production: Current Advances and Prospects.Animals : an open access journal from MDPI · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Genetic and Phenotypic Characteristics of Belted Pig Breeds: A Review.Animals : an open access journal from MDPI · 2023
    Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Samantha WilkinsonThe Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
Zen H Lu
Hendrik-Jan Megens
Alan L Archibald
Chris Haley
Ian J Jackson
Martien A M Groenen
Richard P M A Crooijmans
Rob Ogden
Pamela Wiener
Roslin Institute · GBCentre for BioSystems Genomics · NLUniversity of Edinburgh · GBRoyal Zoological Society of Scotland · GBWageningen University & Research · NL

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/05191132Biotechnology and Biological Sciences Research Council BBS/E/D/05191133Biotechnology and Biological Sciences Research Council BBS/E/D/20211550Biotechnology and Biological Sciences Research Council BBS/E/D/20211554Biotechnology and Biological Sciences Research Council BBS/E/R/00001613European Research Council 249894Medical Research Council MC_PC_U127527200Medical Research Council MC_PC_U127592696Medical Research Council MC_U127592696
6 · The paper itself

Abstract

Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour. To better understand the relationship between genomic composition and phenotypic diversity arising from breed development, the genomes of 13 traditional and commercial European pig breeds were scanned for signatures of diversifying selection using the Porcine60K SNP chip, applying a between-population (differentiation) approach. Signatures of diversifying selection between breeds were found in genomic regions associated with traits related to breed standard criteria, such as coat colour and ear morphology. Amino acid differences in the EDNRB gene appear to be associated with one of these signatures, and variation in the KITLG gene may be associated with another. Other selection signals were found in genomic regions including QTLs and genes associated with production traits such as reproduction, growth, and fat deposition. Some selection signatures were associated with regions showing evidence of introgression from Asian breeds. When the European breeds were compared with wild boar, genomic regions with high levels of differentiation harboured genes related to bone formation, growth, and fat deposition.

Indexed as

BreedingSus scrofaAnimalsGenomeGenomicsPhenotypePolymorphism, Single NucleotideQuantitative Trait LociSelection, GeneticSwine

Identifiers

PMID23637623
PMCPMC3636142
OpenAlexW2000584605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.