ArticlePLoS genetics2013
Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Anatomic and neurochemical analysis of the palpal olfactory system in the red flour beetleFrontiers in cellular neuroscience · 2023Article
- Rapid brain development and reduced neuromodulator titres correlate with host shifts inRoyal Society open science · 2022Article
- A reversal in sensory processing accompanies ongoing ecological divergence and speciation inProceedings. Biological sciences · 2021Article
- Mechanosensory neuron regeneration in adultDevelopment (Cambridge, England) · 2021Article
- The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Serotonergic modulation across sensory modalities.Journal of neurophysiology · 2020Review
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- Article
- Serotonergic Modulation of Olfaction in Rodents and Insects.The Yale journal of biology and medicine · 2018Review
- Correction: Sensory Neuron-Derived Eph Regulates Glomerular Arbors and Modulatory Function of a Central Serotonergic Neuron.PLoS genetics · 2017Article
- Identified Serotonergic Modulatory Neurons Have Heterogeneous Synaptic Connectivity within the Olfactory System ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation inGenes & development · 2017Article
- Intrinsic and Extrinsic Neuromodulation of Olfactory Processing.Frontiers in cellular neuroscience · 2017Review
- Article
- The anatomical basis for modulatory convergence in the antennal lobe of Manduca sexta.The Journal of comparative neurology · 2016Article
- A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila.PloS one · 2016Article
- Development of connectivity in a motoneuronal network in Drosophila larvae.Current biology : CB · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.