ArticlePLoS genetics2013
Insulators target active genes to transcription factories and polycomb-repressed genes to polycomb bodies.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Su(Hw) interacts with Combgap to establish long-range chromatin contacts.Epigenetics & chromatin · 2024Article
- Topological screen identifies hundreds of Cp190- and CTCF-dependentScience advances · 2023Article
- Comparison of genome architecture at two stages of male germline cell differentiation in Drosophila.Nucleic acids research · 2022Article
- Chromatin Hubs: A biological and computational outlook.Computational and structural biotechnology journal · 2022Review
- Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes.Epigenetics & chromatin · 2020Article
- Tidying-up the plant nuclear space: domains, functions, and dynamics.Journal of experimental botany · 2020Review
- Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation.Developmental cell · 2019Article
- Decreased Temperature Sensitivity ofGenes · 2019Article
- Chromatin architecture reorganization during neuronal cell differentiation inGenome research · 2019Article
- The interdependence of gene-regulatory elements and the 3D genome.The Journal of cell biology · 2019Review
- Argonaute2 attenuates active transcription by limiting RNA Polymerase II elongation in Drosophila melanogaster.Scientific reports · 2018Article
- DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis.Epigenetics & chromatin · 2018Article
- Argonaute2 and LaminB modulate gene expression by controlling chromatin topology.PLoS genetics · 2018Article
- Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction.Brain, behavior, and immunity · 2018Article
- Sex combs reduced (Scr) regulatory region of Drosophila revisited.Molecular genetics and genomics : MGG · 2017Article
- Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila.Nature genetics · 2017Article
- Review
- Insulator speckles associated with long-distance chromatin contacts.Biology open · 2016Article
- An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.Molecular cell · 2016Article
- Morphology of nuclear transcription.Histochemistry and cell biology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Polycomb bodies are foci of Polycomb proteins in which different Polycomb target genes are thought to co-localize in the nucleus, looping out from their chromosomal context. We have shown previously that insulators, not Polycomb response elements (PREs), mediate associations among Polycomb Group (PcG) targets to form Polycomb bodies. Here we use live imaging and 3C interactions to show that transgenes containing PREs and endogenous PcG-regulated genes are targeted by insulator proteins to different nuclear structures depending on their state of activity. When two genes are repressed, they co-localize in Polycomb bodies. When both are active, they are targeted to transcription factories in a fashion dependent on Trithorax and enhancer specificity as well as the insulator protein CTCF. In the absence of CTCF, assembly of Polycomb bodies is essentially reduced to those representing genomic clusters of Polycomb target genes. The critical role of Trithorax suggests that stable association with a specialized transcription factory underlies the cellular memory of the active state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.