ArticlePLoS genetics2013
TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- Article
- PGEProceedings of the National Academy of Sciences of the United States of America · 2023Article
- H3K4me1 Modification Functions in Caste Differentiation in Honey Bees.International journal of molecular sciences · 2023Article
- A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling.PLoS pathogens · 2022Article
- What makes a histone variant a variant: Changing H2A to become H2A.Z.PLoS genetics · 2021Article
- Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression.EMBO reports · 2021Article
- Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity.Stem cell reviews and reports · 2020Review
- Epigenetic Mechanisms of Learning and Memory: Implications for Aging.International journal of molecular sciences · 2020Review
- Article
- DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.Nature chemical biology · 2019Article
- The histone variant H2A.Z in gene regulation.Epigenetics & chromatin · 2019Review
- Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.Nucleic acids research · 2018Article
- Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer.Nature communications · 2017Article
- Real-Time Imaging of a Single Gene Reveals Transcription-Initiated Local Confinement.Biophysical journal · 2017Article
- H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.Transcription · 2017Article
- Histone variants on the move: substrates for chromatin dynamics.Nature reviews. Molecular cell biology · 2017Review
- In the loop: promoter-enhancer interactions and bioinformatics.Briefings in bioinformatics · 2016Review
- Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis.Cell reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone variants, including histone H2A.Z, are incorporated into specific genomic sites and participate in transcription regulation. The role of H2A.Z at these sites remains poorly characterized. Our study investigates changes in the chromatin environment at the Cyclin D1 gene (CCND1) during transcriptional initiation in response to estradiol in estrogen receptor positive mammary tumour cells. We show that H2A.Z is present at the transcription start-site and downstream enhancer sequences of CCND1 when the gene is poorly transcribed. Stimulation of CCND1 expression required release of H2A.Z concomitantly from both these DNA elements. The AAA+ family members TIP48/reptin and the histone variant H2A.Z are required to remodel the chromatin environment at CCND1 as a prerequisite for binding of the estrogen receptor (ERα) in the presence of hormone. TIP48 promotes acetylation and exchange of H2A.Z, which triggers a dissociation of the CCND1 3' enhancer from the promoter, thereby releasing a repressive intragenic loop. This release then enables the estrogen receptor to bind to the CCND1 promoter. Our findings provide new insight into the priming of chromatin required for transcription factor access to their target sequence. Dynamic release of gene loops could be a rapid means to remodel chromatin and to stimulate transcription in response to hormones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.