ArticlePLoS biology2013
Directional transport is mediated by a Dynein-dependent step in an RNA localization pathway.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Kinetic Control of Nuclear-encoded Mitochondrial mRNA Localization and Local Translation.bioRxiv : the preprint server for biology · 2026Article
- TheBiomolecules · 2025Review
- Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes.Scientific reports · 2024Article
- Arabidopsis Actin-Binding Protein WLIM2A Links PAMP-Triggered Immunity and Cytoskeleton Organization.International journal of molecular sciences · 2024Article
- Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates inbioRxiv : the preprint server for biology · 2023Article
- Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference.Marine life science & technology · 2023Review
- An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport.The Journal of cell biology · 2023Article
- Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates iniScience · 2022Article
- Remnants of the Balbiani body are required for formation of RNA transport granules iniScience · 2022Article
- Regulation of spatially restricted gene expression: linking RNA localization and phase separation.Biochemical Society transactions · 2021Review
- L-bodies are RNA-protein condensates driving RNA localization inMolecular biology of the cell · 2021Article
- Renewal Reward Perspective on Linear Switching Diffusion Systems in Models of Intracellular Transport.Bulletin of mathematical biology · 2020Article
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- Article
- Fluorescence In Situ Hybridization of CryosectionedCold Spring Harbor protocols · 2018Article
- Modeling microtubule-based transport and anchoring of mRNA.SIAM journal on applied dynamical systems · 2018Article
- Analysis of Active Transport by Fluorescence Recovery after Photobleaching.Biophysical journal · 2017Article
- An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.The EMBO journal · 2017Article
- Maternal messages to live by: a personal historical perspective.Genesis (New York, N.Y. : 2000) · 2017Review
- Using in vivo imaging to measure RNA mobility in Xenopus laevis oocytes.Methods (San Diego, Calif.) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cytoplasmic RNA localization is a key biological strategy for establishing polarity in a variety of organisms and cell types. However, the mechanisms that control directionality during asymmetric RNA transport are not yet clear. To gain insight into this crucial process, we have analyzed the molecular machinery directing polarized transport of RNA to the vegetal cortex in Xenopus oocytes. Using a novel approach to measure directionality of mRNA transport in live oocytes, we observe discrete domains of unidirectional and bidirectional transport that are required for vegetal RNA transport. While kinesin-1 appears to promote bidirectional transport along a microtubule array with mixed polarity, dynein acts first to direct unidirectional transport of RNA towards the vegetal cortex. Thus, vegetal RNA transport occurs through a multistep pathway with a dynein-dependent directional cue. This provides a new framework for understanding the mechanistic basis of cell and developmental polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.