ArticleInternational journal of general medicine2013
Genetic polymorphisms and associated susceptibility to asthma.
Article in International journal of general medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interleukin-13 gene polymorphisms and asthma susceptibility in children: a meta-analysis.BMC pediatrics · 2025Pooled it
- Association of nitric oxide synthase gene polymorphism with asthma: A systematic review and meta-analysis.The clinical respiratory journal · 2023Pooled it
- Potential Determinants of Progression from Cough-Variant Asthma to Classic Asthma in Children: Evidence, Mechanisms, and Clinical Research Gaps.Journal of asthma and allergy · 2026Review
- A review of recent advances in gene therapy, pharmacogenomics, and genetic polymorphisms in asthma.Molecular biology reports · 2025Review
- SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma.International journal of molecular sciences · 2024Observational
- Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population.Respiratory research · 2022Article
- Integrative genetics-metabolomics analysis of infant bronchiolitis-childhood asthma link: A multicenter prospective study.Frontiers in immunology · 2022Article
- Association of Interleukin 13 rs20541 Gene Polymorphism and Serum Periostin with Asthma and Allergic Conjunctivitis Among Egyptian Patients.Journal of asthma and allergy · 2022Article
- BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.American journal of respiratory and critical care medicine · 2019Article
- Association of genetic variants with level of asthma control in the Arab population.Journal of asthma and allergy · 2019Article
- The Study ofTanaffos · 2018Article
- Article
- Identification of Four Novel Loci in Asthma in European American and African American Populations.American journal of respiratory and critical care medicine · 2017Article
- Genotyping ofDisease markers · 2017Article
- Article
- A case-control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma.BMC pulmonary medicine · 2016Article
- New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma.Current allergy and asthma reports · 2016Review
- Identifying a biomarker network for corticosteroid resistance in asthma from bronchoalveolar lavage samples.Molecular biology reports · 2016Article
- Identification of Susceptibility Genes of Adult Asthma in French Canadian Women.Canadian respiratory journal · 2016Article
- I feel you-monitoring environmental variables related to asthma in an integrated real-time frame.BMC research notes · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
As complex common diseases, asthma and allergic diseases are caused by the interaction of multiple genetic variants with a variety of environmental factors. Candidate-gene studies have examined the involvement of a very large list of genes in asthma and allergy, demonstrating a role for more than 100 loci. These studies have elucidated several themes in the biology and pathogenesis of these diseases. A small number of genes have been associated with asthma or allergy through traditional linkage analyses. The publication of the first asthma-focused genome-wide association (GWA) study in 2007 has been followed by nearly 30 reports of GWA studies targeting asthma, allergy, or associated phenotypes and quantitative traits. GWA studies have confirmed several candidate genes and have identified new, unsuspected, and occasionally uncharacterized genes as asthma susceptibility loci. Issues of results replication persist, complicating interpretation and making conclusions difficult to draw, and much of the heritability of these diseases remains undiscovered. In the coming years studies of complex diseases like asthma and allergy will probably involve the use of high-throughput next-generation sequencing, which will bring a tremendous influx of new information as well as new problems in dealing with vast datasets.
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Registered trials
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