Evidence map›Paper›PMID 23637533›Full record

ArticleInternational journal of nanomedicine2013

Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation.

Rene Hernandez-Delgadillo, Donaji Velasco-Arias, Juan Jose Martinez-Sanmiguel, David Diaz, Inti Zumeta-Dube, Katiushka Arevalo-Niño, Claudio Cabral-Romero

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Metal Nanoparticles in Infection and Immunity.Immunological investigations · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Antimicrobial Potency andMolecules (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Bismuth Oxide (BiToxics · 2023
    Article
  12. Article
  13. Review
  14. Microflow synthesis and enhanced photocatalytic dye degradation performance of antibacterial BiEnvironmental science and pollution research international · 2021
    Article
  15. Intestinal Infection ofFrontiers in microbiology · 2021
    Review
  16. Mechanistic Understanding ofFrontiers in microbiology · 2021
    Review
  17. Article
  18. Cytotoxicity of bismuth nanoparticles in the murine macrophage cell line RAW 264.7.Journal of materials science. Materials in medicine · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rene Hernandez-DelgadilloFacultad de Ciencias Biológicas, Instituto de Biotecnologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Mexico.
Donaji Velasco-Arias
Juan Jose Martinez-Sanmiguel
David Diaz
Inti Zumeta-Dube
Katiushka Arevalo-Niño
Claudio Cabral-Romero
Universidad Autónoma de Nuevo León · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi2O3 nanoparticles.

Indexed as

AnimalsAntifungal AgentsBiofilmsBismuthCandida albicansCell ShapeChlorhexidineChlorocebus aethiopsMetal NanoparticlesMicrobial Sensitivity TestsMicroscopy, FluorescenceNaphthalenesTerbinafineVero CellsAntifungal AgentsBismuthbismuth oxideChlorhexidineNaphthalenesTerbinafineantifungalantimycotic agentcytotoxicity

Identifiers

PMID23637533
PMCPMC3639116
OpenAlexW2026097247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.