ArticleDiabetes care2013
The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
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- Identification of key regulatory genes and their working mechanisms in type 1 diabetes.BMC medical genomics · 2023Article
- Aberration in myeloid-derived pro-angiogenic cells in type-2 diabetes mellitus; implication for diabetic retinopathy?Frontiers in ophthalmology · 2023Article
- Single-Cell Profiling of Tumor-Associated Neutrophils in Advanced Non-Small Cell Lung Cancer.Lung Cancer (Auckland, N.Z.) · 2023Article
- Skeletal manifestations in a streptozotocin-induced C57BL/6 model of Type 1 diabetes.Bone reports · 2022Article
- Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus.Journal of diabetes investigation · 2022Article
- Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing.International immunopharmacology · 2022Article
- Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice.Molecular metabolism · 2022Article
- Transforming Growth Factor-β1 and Receptor for Advanced Glycation End Products Gene Expression and Protein Levels in Adolescents with Type 1 iabetes MellitusJournal of clinical research in pediatric endocrinology · 2021Article
- Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery.Adipocyte · 2020Article
- Ablation of Myeloid Cell MRP8 Ameliorates Nephrotoxic Serum-induced Glomerulonephritis by Affecting Macrophage Characterization through Intraglomerular Crosstalk.Scientific reports · 2020Article
- Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions.Frontiers in immunology · 2020Article
- Inhibition of miR-21 alleviated cardiac perivascular fibrosis via repressing EndMT in T1DM.Journal of cellular and molecular medicine · 2020Article
- Effects of preservation duration at 4 °C on the quality of RNA in rabbit blood specimens.PeerJ · 2020Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOur previous gene expression microarray studies identified a number of genes differentially expressed in patients with type 1 diabetes (T1D) and islet autoantibody-positive subjects. This study was designed to validate these gene expression changes in T1D patients and to identify gene expression changes in diabetes complications. RESEARCH DESIGH AND
methodsWe performed high-throughput real-time RT-PCR to validate gene expression changes in peripheral blood mononuclear cells (PBMCs) from a large sample set of 928 T1D patients and 922 control subjects.
resultsOf the 18 genes analyzed here, eight genes (S100A8, S100A9, MNDA, SELL, TGFB1, PSMB3, CD74, and IL12A) had higher expression and three genes (GNLY, PSMA4, and SMAD7) had lower expression in T1D patients compared with control subjects, indicating that genes involved in inflammation, immune regulation, and antigen processing and presentation are significantly altered in PBMCs from T1D patients. Furthermore, one adhesion molecule (SELL) and three inflammatory genes mainly expressed by myeloid cells (S100A8, S100A9, and MNDA) were significantly higher in T1D patients with complications (odds ratio [OR] 1.3-2.6, adjusted P value = 0.005-10(-8)), especially those patients with neuropathy (OR 4.8-7.9, adjusted P value <0.005).
conclusionsThese findings suggest that inflammatory mediators secreted mainly by myeloid cells are implicated in T1D and its complications.
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