ArticleDevelopment (Cambridge, England)2013
Elastogenesis at the onset of human cardiac valve development.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Computational analysis of heart valve growth and remodeling after the Ross procedure.Biomechanics and modeling in mechanobiology · 2024Article
- Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve.Scientific reports · 2024Article
- APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling.Nature cardiovascular research · 2024Article
- Differential Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve.Journal of cardiovascular development and disease · 2024Article
- Angiopoietin-like 2 is essential to aortic valve development in mice.Communications biology · 2022Article
- 3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development.Journal of the American Society of Nephrology : JASN · 2021Article
- Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease.Journal of cardiovascular development and disease · 2021Article
- Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve.Frontiers in cardiovascular medicine · 2021Review
- Transglutaminase 2 moderates the expansion of mouse abdominal aortic aneurysms.JVS-vascular science · 2021Article
- A Functional Variant Rs492554 Associated With Congenital Heart Defects ModulatesFrontiers in cell and developmental biology · 2021Article
- Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.Frontiers in cardiovascular medicine · 2021Article
- New Concepts in the Development and Malformation of the Arterial Valves.Journal of cardiovascular development and disease · 2020Review
- Mechanisms of heart valve development and disease.Development (Cambridge, England) · 2020Review
- Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- Small Caliber Compliant Vascular Grafts Based on Elastin-Like Recombinamers forFrontiers in bioengineering and biotechnology · 2019Article
- A heart for fibrillin: spatial arrangement in adult wild-type murine myocardial tissue.Histochemistry and cell biology · 2018Article
- Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.Frontiers in cardiovascular medicine · 2018Article
- Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals.Stem cell reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Semilunar valve leaflets have a well-described trilaminar histoarchitecture, with a sophisticated elastic fiber network. It was previously proposed that elastin-containing fibers play a subordinate role in early human cardiac valve development; however, this assumption was based on data obtained from mouse models and human second and third trimester tissues. Here, we systematically analyzed tissues from human fetal first (4-12 weeks) and second (13-18 weeks) trimester, adolescent (14-19 years) and adult (50-55 years) hearts to monitor the temporal and spatial distribution of elastic fibers, focusing on semilunar valves. Global expression analyses revealed that the transcription of genes essential for elastic fiber formation starts early within the first trimester. These data were confirmed by quantitative PCR and immunohistochemistry employing antibodies that recognize fibronectin, fibrillin 1, 2 and 3, EMILIN1 and fibulin 4 and 5, which were all expressed at the onset of cardiac cushion formation (~week 4 of development). Tropoelastin/elastin protein expression was first detectable in leaflets of 7-week hearts. We revealed that immature elastic fibers are organized in early human cardiovascular development and that mature elastin-containing fibers first evolve in semilunar valves when blood pressure and heartbeat accelerate. Our findings provide a conceptual framework with the potential to offer novel insights into human cardiac valve development and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.