ArticleDevelopment (Cambridge, England)2013
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Transcription Factor TAL1 in Erythropoiesis.Advances in experimental medicine and biology · 2024Review
- Engineered hematopoietic and immune cells derived from human pluripotent stem cells.Experimental hematology · 2023Review
- De Novo Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells for Cellular Therapy.Cells · 2023Review
- Identification and validation of aging-related gene signatures and their immune landscape in diabetic nephropathy.Frontiers in medicine · 2023Article
- Article
- The Evolution of Biomineralization through the Co-Option of Organic Scaffold Forming Networks.Cells · 2022Review
- Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment.Annals of the New York Academy of Sciences · 2020Review
- A Bird's Eye View on the Origin of Aortic Hemogenic Endothelial Cells.Frontiers in cell and developmental biology · 2020Article
- Review
- Possible cooption of a VEGF-driven tubulogenesis program for biomineralization in echinoderms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos.Nature communications · 2019Article
- New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images.PLoS computational biology · 2018Article
- Navigating Xenbase: An Integrated Xenopus Genomics and Gene Expression Database.Methods in molecular biology (Clifton, N.J.) · 2018Article
- A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.The Journal of experimental medicine · 2017Article
- Inhibition of Vascular Endothelial Growth Factor Receptor Decreases Regenerative Angiogenesis in Axolotls.Anatomical record (Hoboken, N.J. : 2007) · 2017Article
- Adipose tissue macrophages develop from bone marrow-independent progenitors inJournal of leukocyte biology · 2017Article
- Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells.Nature protocols · 2017Article
- Research proceedings on amphibian model organisms.Dong wu xue yan jiu = Zoological research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The first haematopoietic stem cells share a common origin with the dorsal aorta and derive from putative adult haemangioblasts in the dorsal lateral plate (DLP) mesoderm. Here we show that the transcription factor (TF) stem cell leukaemia (Scl/Tal1) is crucial for development of these adult haemangioblasts in Xenopus and establish the regulatory cascade controlling its expression. We show that VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent DLP by establishing endogenous VEGFA signalling. This response depends on expression of the VEGF receptor Flk1, driven by Fli1 and Gata2. Scl activation requires synergy between this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/Etsrp/ER71, which also drives expression of the Scl partner Lmo2. Thus, the two ETS factors Fli1 and Etv6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the adult haemangioblast gene regulatory network (GRN). Furthermore, Gata2 is initially activated by Fli1 but later maintained by another ETS factor, Etv2. We also establish that Flk1 and Etv2 act independently in the two pathways to Scl activation. Thus, detailed temporal, epistatic measurements of key TFs and VEGFA plus its receptor have enabled us to build a Xenopus adult haemangioblast GRN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.