Evidence map›Paper›PMID 23637325›Full record

ArticleThe Journal of rheumatology2013

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.

Paula S Ramos, James C Oates, Diane L Kamen, Adrienne H Williams, Patrick M Gaffney, Jennifer A Kelly, Kenneth M Kaufman, Robert P Kimberly, Timothy B Niewold, Chaim O Jacob and 22 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Ancestry and genetic associations with bronchopulmonary dysplasia in preterm infants.American journal of physiology. Lung cellular and molecular physiology · 2018
    Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

32 authors at 18 institutions in 3 countries.

Paula S RamosDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA. ramosp@musc.edu
James C Oates
Diane L Kamen
Adrienne H Williams
Patrick M Gaffney
Jennifer A Kelly
Kenneth M Kaufman
Robert P Kimberly
Timothy B Niewold
Chaim O Jacob
Betty P Tsao
Graciela S Alarcón
Elizabeth E Brown
Jeffrey C Edberg
Michelle A Petri
Rosalind Ramsey-Goldman
John D Reveille
Luis M Vilá
Judith A James
Joel M Guthridge
Joan T Merrill
Susan A Boackle
Barry I Freedman
R Hal Scofield
Anne M Stevens
Timothy J Vyse
Lindsey A Criswell
Kathy L Moser
Marta E Alarcón-Riquelme
Carl D Langefeld
John B Harley
Gary S Gilkeson
Oklahoma Medical Research Foundation · USMedical University of South Carolina · USUniversity of Alabama at Birmingham · USWake Forest University · USCincinnati Children's Hospital Medical Center · USCenter for Rheumatology · USJohns Hopkins University · USKing's College London · GBNorthwestern University · USSouthern California University for Professional Studies · USThe University of Texas Health Science Center at Houston · USUniversidad de Granada · ESUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Colorado Denver · USUniversity of Oklahoma · USUniversity of Washington · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
MULTIDISCIPLINARY CLINICAL AND TRANSLATIONAL SCIENCE (MCTS) PROGRAM (UL1)UL1RR025741 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$24.7M
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1: BPCAUL1RR025777 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUAY-WOODFORD, LISA MARIE · 2008 to 2011
$22.3M
VALIDATING NOVEL GENES IMPLICATED IN LEUKOCYTE CHEMOTAXISP20RR020143 · NCRR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2004 to 2011
$21.0M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
ZINC AND COPPER METABOLISM IN COLLAGEN DISORDERSM01RR001070 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI REVES, JOSEPH G · 1985 to 2009
$16.3M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
BLRD VA I01 BX001834NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000154NCI NIH HHS P30 CA046934NCRR NIH HHS 5 M01 RR-00079NCRR NIH HHS 5UL1 RR025777NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR001070NCRR NIH HHS P20 RR020143NCRR NIH HHS P30 RR031152NCRR NIH HHS RR020143NCRR NIH HHS RR031152NCRR NIH HHS U54 RR026107NCRR NIH HHS UL 1 RR025741NCRR NIH HHS UL1 RR025741NCRR NIH HHS UL1 RR025777NCRR NIH HHS UL1 RR029882NIAID NIH HHS AI024717NIAID NIH HHS AI082714NIAID NIH HHS AI101934NIAID NIH HHS K24 AI078004NIAID NIH HHS R01 AI024717NIAID NIH HHS R01 AI063274NIAID NIH HHS R21 AI070304NIAID NIH HHS R37 AI024717NIAID NIH HHS U01 AI101934NIAID NIH HHS U19 AI082714NIAMS NIH HHS AR042460NIAMS NIH HHS AR053843NIAMS NIH HHS AR058554NIAMS NIH HHS AR43727NIAMS NIH HHS K24 AR002138NIAMS NIH HHS K24 AR002175NIAMS NIH HHS K24 AR02175NIAMS NIH HHS N01 AR062277NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P01 AR49084NIAMS NIH HHS P30 AR050948NIAMS NIH HHS P30 AR053483NIAMS NIH HHS P30 AR055385NIAMS NIH HHS P60 2 AR30692NIAMS NIH HHS P60 AR030692NIAMS NIH HHS P60 AR053308NIAMS NIH HHS P60 AR062755NIAMS NIH HHS R01 AR033062NIAMS NIH HHS R01 AR042460NIAMS NIH HHS R01 AR043274NIAMS NIH HHS R01 AR043727NIAMS NIH HHS R01 AR043814NIAMS NIH HHS R01 AR044804NIAMS NIH HHS R01 AR045476NIAMS NIH HHS R01 AR045650NIAMS NIH HHS R01 AR053843NIAMS NIH HHS R01 AR057172NIAMS NIH HHS R01 AR33062NIAMS NIH HHS R01 AR445650NIAMS NIH HHS R01 AR44804NIAMS NIH HHS R01 AR45476NIAMS NIH HHS RC1 AR058554NIEHS NIH HHS P30 ES006096Wellcome Trust
6 · The paper itself

Abstract

objectiveLittle is known about the genetic etiology of systemic lupus erythematosus (SLE) in individuals of African ancestry, despite its higher prevalence and greater disease severity. Overproduction of nitric oxide (NO) and reactive oxygen species are implicated in the pathogenesis and severity of SLE, making NO synthases and other reactive intermediate-related genes biological candidates for disease susceptibility. We analyzed variation in reactive intermediate genes for association with SLE in 2 populations with African ancestry.

methodsA total of 244 single-nucleotide polymorphisms (SNP) from 53 regions were analyzed in non-Gullah African Americans (AA; 1432 cases and 1687 controls) and the genetically more homogeneous Gullah of the Sea Islands of South Carolina (133 cases and 112 controls). Single-marker, haplotype, and 2-locus interaction tests were computed for these populations.

resultsThe glutathione reductase gene GSR (rs2253409; p = 0.0014, OR 1.26, 95% CI 1.09-1.44) was the most significant single SNP association in AA. In the Gullah, the NADH dehydrogenase NDUFS4 (rs381575; p = 0.0065, OR 2.10, 95% CI 1.23-3.59) and NO synthase gene NOS1 (rs561712; p = 0.0072, OR 0.62, 95% CI 0.44-0.88) were most strongly associated with SLE. When both populations were analyzed together, GSR remained the most significant effect (rs2253409; p = 0.00072, OR 1.26, 95% CI 1.10-1.44). Haplotype and 2-locus interaction analyses also uncovered different loci in each population.

conclusionThese results suggest distinct patterns of association with SLE in African-derived populations; specific loci may be more strongly associated within select population groups.

Indexed as

Genetic Predisposition to DiseaseAdultAllelesBlack or African AmericanBlack PeopleElectron Transport Complex IGenetic Association StudiesGenetic LociGenotypeGlutathione ReductaseHaplotypesHumansLupus Erythematosus, SystemicNADH DehydrogenaseNitric Oxide Synthase Type IPolymorphism, Single NucleotideElectron Transport Complex IGlutathione ReductaseNADH DehydrogenaseNDUFS4 protein, humanNitric Oxide Synthase Type INOS1 protein, humanAFRICAN AMERICANSGENETIC ASSOCIATION STUDIESOXYGEN COMPOUNDSSINGLE-NUCLEOTIDE POLYMORPHISMSYSTEMIC LUPUS ERYTHEMATOSUS

Identifiers

PMID23637325
PMCPMC3735344
OpenAlexW2146656611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.