Evidence map›Paper›PMID 23637108›Full record

SynthesisThe British journal of psychiatry : the journal of mental science2013

Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies.

Breno S Diniz, Meryl A Butters, Steven M Albert, Mary Amanda Dew, Charles F Reynolds

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of psychiatry : the journal of mental science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 586 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
586citing papers in PubMed, 8 pooled it
43.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02303158 terminatednot on this mapstarted 2014, after this paper: background citation

Study of the Relationship Between Protein Biomarkers in Cerebrospinal Fluid and the Risk of Progression to Alzheimer&Apos;s Disease in a Cohort of Patients With Depression

TypeobservationalSponsorInstitut Investigacio Sanitaria Pere VirgiliRan2014 to 2018Enrolled50ConditionsAlzheimer's Disease
NCT06914284 recruitingnot on this mapstarted 2024, after this paper: background citation

Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept

TypeobservationalSponsorHospital Center Guillaume RégnierRan2024 to 2029Enrolled30ConditionsApathy, Bipolar DisorderArmsActigraphy and MRI
3 · Its place in the literature

Who cites it

586 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,263 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Trial
  10. Trial
  11. The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024
    Trial
  12. Trial
  13. Article
  14. Depression and anxiety in vascular dementia: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

526 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Breno S DinizDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Meryl A Butters
Steven M Albert
Mary Amanda Dew
Charles F Reynolds
University of Pittsburgh · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEW, MARY AMANDA · 2011 to 2015
$8.3M
Amyloid, White Matter Hyperintensities & Outcomes of Late-Life DepressionR01MH080240 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2009 to 2014
$2.6M
Pathways Linking Late-Life Depression to MCI &DementiaR01MH072947 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2005 to 2009
$2.0M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCRR NIH HHS UL1 RR024153NIA NIH HHS P30 AG024827NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH072947NIMH NIH HHS R01 MH080240
6 · The paper itself

Abstract

backgroundLate-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia.

aimsTo conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies.

methodA total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression.

resultsLate-life depression was associated with a significant risk of all-cause dementia (1.85, 95% CI 1.67-2.04, P<0.001), Alzheimer's disease (1.65, 95% CI 1.42-1.92, P<0.001) and vascular dementia (2.52, 95% CI 1.77-3.59, P<0.001). Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P = 0.03).

conclusionsLate-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease.

Indexed as

AdolescentAdultAgedAged, 80 and overAlzheimer DiseaseChildDementia, VascularDepressive DisorderFemaleHumansMaleMiddle AgedRisk FactorsYoung Adult

Identifiers

PMID23637108
PMCPMC3640214
OpenAlexW2142827889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.