ArticleAntiviral chemistry & chemotherapy2014
Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.
Article in Antiviral chemistry & chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action.Journal of biomolecular structure & dynamics · 2022Article
- Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.Reviews in medical virology · 2021Review
- Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2.Cell cycle (Georgetown, Tex.) · 2020Article
- Vitamin A Supplementation Was Associated with Reduced Mortality in Patients with Ebola Virus Disease during the West African Outbreak.The Journal of nutrition · 2019Article
- A new oxygen modification cyclooctaoxygen binds to nucleic acids as sodium crown complex.Biochimica et biophysica acta · 2016Article
- Development of Small-Molecule Antivirals for Ebola.Medicinal research reviews · 2015Review
- Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection.F1000Research · 2015Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundHuman HBV and HIV integrate their retro-transcribed DNA proviruses into the human host genome. Existing antiretroviral drug regimens fail to directly target these intrachromosomal xenogenomes, leading to persistence of viral genetic information. Retinazone (RTZ) constitutes a novel vitamin A-derived (retinoid) thiosemicarbazone derivative with broad-spectrum antiviral activity versus HIV, HCV, varicella-zoster virus and cytomegalovirus.
methodsThe in vitro inhibitory action of RTZ on HIV-1 strain LAI, human HBV strain ayw, HCV-1b strain Con1, enhanced green fluorescent protein-expressing Ebola virus Zaire 1976 strain Mayinga, wild-type Ebola virus Zaire 1976 strain Mayinga, human herpesvirus 6B and Kaposi's sarcoma-associated herpesvirus replication was investigated. The binding of RTZ to human glucocorticoid receptor was determined.
resultsRTZ inhibits blood-borne human HBV multiplication in vitro by covalent inactivation of intragenic and intraexonic viral glucocorticoid response elements, and, in close analogy, RTZ suppresses HIV-1 multiplication in vitro. RTZ disrupts the multiplication of blood-borne human HCV and Ebola Zaire virus at nanomolar concentrations in vitro. RTZ has the capacity to bind to human glucocorticoid receptor, to selectively and covalently bind to intraexonic viral glucocorticoid response elements, and thereby to inactivate human genome-integrated proviral DNA of human HBV and HIV.
conclusionsRTZ represents the first reported antiviral agent capable of eradicating HIV and HBV proviruses from their human host. Furthermore, RTZ represents a potent and efficacious small-molecule in vitro inhibitor of Ebola virus Zaire 1976 strain Mayinga replication.
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