ReviewPflugers Archiv : European journal of physiology2013
New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Distinct behavioral response of primary motor cortex stimulation in itch and pain after burn injury.Neuroscience letters · 2019Trial
- Altered sensory neuron activity in a mouse model of post-burn pain and itch.Scientific reports · 2026Article
- Psychopharmacology in Dermatology.Indian dermatology online journal · 2026Article
- Altered sensory neuron activity in a mouse model of post-burn pain and itch.Research square · 2026Article
- CRH neurons in the AM-ACC circuit drive chronic pain and anxiety comorbidity.Frontiers in neuroscience · 2026Article
- Short-term and patient-reported outcomes of laser hemorrhoidoplasty plus excisional hemorrhoidectomy for the treatment of grade IV hemorrhoid.Scientific reports · 2025Article
- The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review.European journal of pain (London, England) · 2025Review
- Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice.Nature communications · 2025Article
- Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review.Dermatology and therapy · 2024Review
- Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The lateral habenula nucleus regulates pruritic sensation and emotion.Molecular brain · 2023Article
- Trisubstituted 1,3,5-Triazines as Histamine HMolecules (Basel, Switzerland) · 2023Article
- An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in Mice.Neuroscience bulletin · 2023Article
- Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma.The Journal of clinical investigation · 2023Article
- Review
- How Does Botulinum Toxin Inhibit Itch?Toxins · 2022Review
- Identifying and Quantifying the Role of Inflammation in Pain Reduction for Patients With Psoriatic Arthritis Treated With Tofacitinib: A Mediation Analysis.Rheumatology and therapy · 2022Article
- Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects.Pharmaceuticals (Basel, Switzerland) · 2022Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Itch and pain are closely related but distinct sensations. They share largely overlapping mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch-mediating primary sensory neurons are equipped with distinct receptors and ion channels for itch transduction, including Mas-related G protein-coupled receptors (Mrgprs), protease-activated receptors, histamine receptors, bile acid receptor, toll-like receptors, and transient receptor potential subfamily V1/A1 (TRPV1/A1). Recent progress has indicated the existence of an itch-specific neuronal circuitry. The MrgprA3-expressing primary sensory neurons exclusively innervate the epidermis of skin, and their central axons connect with gastrin-releasing peptide receptor (GRPR)-expressing neurons in the superficial spinal cord. Notably, ablation of MrgprA3-expressing primary sensory neurons or GRPR-expressing spinal cord neurons results in selective reduction in itch but not pain. Chronic itch results from dysfunction of the immune and nervous system and can manifest as neural plasticity despite the fact that chronic itch is often treated by dermatologists. While differences between acute pain and acute itch are striking, chronic itch and chronic pain share many similar mechanisms, including peripheral sensitization (increased responses of primary sensory neurons to itch and pain mediators), central sensitization (hyperactivity of spinal projection neurons and excitatory interneurons), loss of inhibitory control in the spinal cord, and neuro-immune and neuro-glial interactions. Notably, painful stimuli can elicit itch in some chronic conditions (e.g., atopic dermatitis), and some drugs for treating chronic pain are also effective in chronic itch. Thus, itch and pain have more similarities in pathological and chronic conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.