ArticleJAMA psychiatry2013
A prospective assessment of reports of drinking to self-medicate mood symptoms with the incidence and persistence of alcohol dependence.
Article in JAMA psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 5 of them syntheses that pooled it.
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Who cites it
92 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Design and development of a mobile-based self-care application for patients with depression and anxiety disorders.BMC medical informatics and decision making · 2023Pooled it
- Posttraumatic stress disorder, drinking to cope, and harmful alcohol use: A multivariate meta-analysis of the self-medication hypothesis.Journal of psychopathology and clinical science · 2022Pooled it
- Alcohol and other substance use during the COVID-19 pandemic: A systematic review.Drug and alcohol dependence · 2021Pooled it
- A systematic review and meta-analysis on the association between solitary drinking and alcohol problems in adults.Addiction (Abingdon, England) · 2021Pooled it
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.JAMA psychiatry · 2017Pooled it
- Same-day, cross-day, and upward spiral relations between positive affect and positive health behaviours.Psychology & health · 2021Trial
- Ultra-brief breath counting (mindfulness) training promotes recovery from stress-induced alcohol-seeking in student drinkers.Addictive behaviors · 2020Trial
- The relationship between smoking cessation and binge drinking, depression, and anxiety symptoms among smokers with serious mental illness.Drug and alcohol dependence · 2019Trial
- Drinking to cope with negative emotions moderates alcohol use disorder treatment response in patients with co-occurring anxiety disorder.Drug and alcohol dependence · 2016Trial
- The impact of focusing a program to prevent heavier drinking on a pre-existing phenotype, the low level of response to alcohol.Alcoholism, clinical and experimental research · 2015Trial
- A prospective co-twin control analysis of internalizing and externalizing pathways for alcohol, nicotine, and cannabis use problems from adolescence through adulthood.Psychological medicine · 2026Article
- Psychological distress and drinking patterns among working-age adults in Japan: a population-based analysis.BMC public health · 2026Article
- Do Internalizing Syndromes have Incremental Validity for External Criteria Above and Beyond Each Other?Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Early Trajectory of Depressive Symptoms in Alcohol Dependence: Insights From a Four-Week Clinical Decision Window.Cureus · 2026Article
- Historical trends in young adult solitary alcohol use by age and sex from 1977 to 2022.Alcohol, clinical & experimental research · 2025Article
- The Spectrum of Psychiatric Comorbidity in Individuals With Inflammatory Bowel Disease.Crohn's & colitis 360 · 2025Article
- The power of emotion regulation: how managing sadness influences depression and anxiety?BMC psychology · 2025Article
- Drinking contexts, coping motive, simultaneous cannabis use, and high-intensity drinking among adults in the United States.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Cracking the code: unveiling the nexus between atopic dermatitis and addictive behavior: a cross-sectional exploration of risk factors.Archives of dermatological research · 2024Article
- Age-related patterns in high-risk alcohol and cannabis use and their associations with positive and negative affect in young adulthood.Addictive behaviors · 2024Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
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Funding
Abstract
importanceMood disorders and alcohol dependence frequently co-occur. Etiologic theories concerning the comorbidity often focus on drinking to self-medicate or cope with affective symptoms. However, there have been few, if any, prospective studies in population-based samples of alcohol self-medication of mood symptoms with the occurrence of alcohol dependence. Furthermore, it is not known whether these associations are affected by treatment or symptom severity.
objectiveTo evaluate the hypothesis that alcohol self-medication of mood symptoms increases the probability of subsequent onset and the persistence or chronicity of alcohol dependence.
designProspective study using face-to-face interviews-the National Epidemiologic Survey on Alcohol and Related Conditions.
settingNationally representative survey of the US population.
participantsDrinkers at risk for alcohol dependence among the 43 093 adults surveyed in 2001 and 2002 (wave 1); 34 653 of whom were reinterviewed in 2004 and 2005 (wave 2). MAIN OUTCOMES AND MEASURES: Association of alcohol self-medication of mood symptoms with incident and persistent DSM-IV alcohol dependence using logistic regression and the propensity score method of inverse probability of treatment weighting.
resultsThe report of alcohol self-medication of mood symptoms was associated with an increased odds of incident alcohol dependence at follow-up (adjusted odds ratio [AOR], 3.10; 95% CI, 1.55-6.19; P = .002) and persistence of dependence (AOR, 3.45; 95% CI, 2.35-5.08; P < .001). The population-attributable fraction was 11.9% (95% CI, 6.7%-16.9%) for incident dependence and 30.6% (95% CI, 24.8%-36.0%) for persistent dependence. Stratified analyses were conducted by age, sex, race/ethnicity, mood symptom severity, and treatment history for mood symptoms. CONCLUSIONS AND RELEVANCE: Drinking to alleviate mood symptoms is associated with the development of alcohol dependence and its persistence once dependence develops. These associations occur among individuals with subthreshold mood symptoms, with DSM-IV affective disorders, and for those who have received treatment. Drinking to self-medicate mood symptoms may be a potential target for prevention and early intervention efforts aimed at reducing the occurrence of alcohol dependence.
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