ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2013
Asthma and the immune response to MMR vaccine viruses in Somali immigrant children: a cross-sectional retrospective cohort study.
Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- New Checkbox, Now What? A Scoping Review to Guide Health Research among Middle Eastern and North African Communities.Journal of racial and ethnic health disparities · 2026Article
- A Scoping Review of the Health of African Immigrant and Refugee Children.International journal of environmental research and public health · 2021Article
- Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease?The Journal of allergy and clinical immunology · 2014Review
- Asthma prevalence and humoral immune response in Somali immigrants in the US: implications for the hygiene hypothesis.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Article
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5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAccording to the 'hygiene hypothesis', an increase in microbial exposure in childhood leads to a T-helper cell 1 (Th1) predominant immune response and protection against asthma and atopic conditions.
aimsTo assess the prevalence of asthma and other atopic conditions in Somali immigrants and to determine the humoral immune response to the measles, mumps, and rubella (MMR) vaccine viruses in Somali immigrants with asthma.
methodsA retrospective cohort study was conducted in Olmsted County, Minnesota. Study subjects were Somali immigrants who were born and lived in Africa during childhood and immigrated to the USA. The subjects had participated in a previous MMR vaccine study. Asthma was ascertained using predetermined asthma criteria after a thorough medical record review. An atopic condition was determined from physician-diagnosed ICD codes. Virus-specific IgG levels in response to the MMR vaccine viruses were determined using an enzyme immunoassay.
resultsOf the 62 eligible subjects, 33 (53%) were female and 29 (47%) were male; 10 (16%) had asthma and 22 (35%) had other atopic conditions. There was no difference in the rubella (p=0.150) and measles (p=0.715) virus-specific IgG levels between the subjects with and without asthma. Mumps virus-specific IgG antibody levels were lower in those with asthma than in those without asthma (mean±SE 2.08±0.28 vs. 3.06±0.14, p=0.005).
conclusionsOur study results may not support the hygiene hypothesis. In addition, the previously reported abnormal T-cell development in Caucasian children with atopy can be considered even in Somali immigrants.
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