ArticleAnnals of biomedical engineering2013
Mechanics of the mitral annulus in chronic ischemic cardiomyopathy.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Morphological Variation in the Human Mitral Valve Using Statistical Shape Modelling.Annals of biomedical engineering · 2026Article
- Large animal models of ischemic mitral regurgitation-systematic review and meta-analysis.Frontiers in medical technology · 2025Article
- Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves.Annals of biomedical engineering · 2024Article
- Geometric data of commercially available tricuspid valve annuloplasty devices.Data in brief · 2024Article
- An analytical, mathematical annuloplasty ring curvature model for planning of valve-in-ring transcatheter mitral valve replacement.JTCVS techniques · 2023Article
- Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2023Review
- A pilot investigation of the tricuspid valve annulus in newborns with hypoplastic left heart syndrome.JTCVS open · 2022Article
- The role of surgery for secondary mitral regurgitation and heart failure in the era of transcatheter mitral valve therapies.Reviews in cardiovascular medicine · 2022Review
- Ex Vivo Model of Ischemic Mitral Regurgitation and Analysis of Adjunctive Papillary Muscle Repair.Annals of biomedical engineering · 2021Article
- Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Tricuspid Valve Annuloplasty Alters Leaflet Mechanics.Annals of biomedical engineering · 2020Article
- An efficient and accurate method for modeling nonlinear fractional viscoelastic biomaterials.Computer methods in applied mechanics and engineering · 2020Article
- The Effect of Downsizing on the Normal Tricuspid Annulus.Annals of biomedical engineering · 2020Article
- Biomechanics of the Tricuspid Annulus: A Review of the Annulus'Mitteilungen der Gesellschaft fur Angewandte Mathematik und Mechanik · 2019Article
- Effect of glutaraldehyde based cross-linking on the viscoelasticity of mitral valve basal chordae tendineae.Biomedical engineering online · 2018Article
- Interpreting Activation Mapping of Atrial Fibrillation: A Hybrid Computational/Physiological Study.Annals of biomedical engineering · 2018Article
- A virtual sizing tool for mitral valve annuloplasty.International journal for numerical methods in biomedical engineering · 2017Article
- Numerical prediction of thrombus risk in an anatomically dilated left ventricle: the effect of inflow cannula designs.Biomedical engineering online · 2016Article
- Modeling Pathologies of Diastolic and Systolic Heart Failure.Annals of biomedical engineering · 2016Article
- Increased systolic load causes adverse remodeling of fetal aortic and mitral valves.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Approximately one third of all patients undergoing open-heart surgery for repair of ischemic mitral regurgitation present with residual and recurrent mitral valve leakage upon follow up. A fundamental quantitative understanding of mitral valve remodeling following myocardial infarction may hold the key to improved medical devices and better treatment outcomes. Here we quantify mitral annular strains and curvature in nine sheep 5 ± 1 weeks after controlled inferior myocardial infarction of the left ventricle. We complement our marker-based mechanical analysis of the remodeling mitral valve by common clinical measures of annular geometry before and after the infarct. After 5 ± 1 weeks, the mitral annulus dilated in septal-lateral direction by 15.2% (p = 0.003) and in commissure-commissure direction by 14.2% (p < 0.001). The septal annulus dilated by 10.4% (p = 0.013) and the lateral annulus dilated by 18.4% (p < 0.001). Remarkably, in animals with large degree of mitral regurgitation and annular remodeling, the annulus dilated asymmetrically with larger distortions toward the lateral-posterior segment. Strain analysis revealed average tensile strains of 25% over most of the annulus with exception for the lateral-posterior segment, where tensile strains were 50% and higher. Annular dilation and peak strains were closely correlated to the degree of mitral regurgitation. A complementary relative curvature analysis revealed a homogenous curvature decrease associated with significant annular circularization. All curvature profiles displayed distinct points of peak curvature disturbing the overall homogenous pattern. These hinge points may be the mechanistic origin for the asymmetric annular deformation following inferior myocardial infarction. In the future, this new insight into the mechanism of asymmetric annular dilation may support improved device designs and possibly aid surgeons in reconstructing healthy annular geometry during mitral valve repair.
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