ArticleMolecular imaging and biology2013
Dual-tracer PET using generalized factor analysis of dynamic sequences.
Article in Molecular imaging and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Kinetic model-informed deep learning for multiplexed PET image separation.EJNMMI physics · 2024Article
- Signal separation of simultaneous dual-tracer PET imaging based on global spatial information and channel attention.EJNMMI physics · 2024Article
- Deep learned triple-tracer multiplexed PET myocardial image separation.Frontiers in nuclear medicine · 2024Article
- Direct reconstruction for simultaneous dual-tracer PET imaging based on multi-task learning.EJNMMI research · 2023Article
- Simultaneous radiomethylation of [Scientific reports · 2022Article
- Quantitation of multiple injection dynamic PET scans: an investigation of the benefits of pooling data from separate scans when mapping kinetics.Physics in medicine and biology · 2021Article
- PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020Article
- Dynamic whole-body PET imaging: principles, potentials and applications.European journal of nuclear medicine and molecular imaging · 2019Review
- Multi-Tracer Guided PET Image Reconstruction.IEEE transactions on radiation and plasma medical sciences · 2018Article
- [Kinetic cluster and α-divergence-based dynamic myocardial factorial analysis of positron-emission computed tomography images].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.Annual review of biomedical engineering · 2015Review
- EM reconstruction of dual isotope PET using staggered injections and prompt gamma positron emitters.Medical physics · 2014Article
- Single-scan dual-tracer FLT+FDG PET tumor characterization.Physics in medicine and biology · 2013Article
- Comparative Study on Effective Dose and Cancer Risk in Dual-tracer Hybrid Imaging - International Commission on Radiological Protection and Personalized Models.Journal of medical physicsArticle
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Authors and funding
5 authors.
Funding
Abstract
purposeWith single-photon emission computed tomography, simultaneous imaging of two physiological processes relies on discrimination of the energy of the emitted gamma rays, whereas the application of dual-tracer imaging to positron emission tomography (PET) imaging has been limited by the characteristic 511-keV emissions. PROCEDURES: To address this limitation, we developed a novel approach based on generalized factor analysis of dynamic sequences (GFADS) that exploits spatio-temporal differences between radiotracers and applied it to near-simultaneous imaging of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) (brain metabolism) and (11)C-raclopride (D2) with simulated human data and experimental rhesus monkey data. We show theoretically and verify by simulation and measurement that GFADS can separate FDG and raclopride measurements that are made nearly simultaneously.
resultsThe theoretical development shows that GFADS can decompose the studies at several levels: (1) It decomposes the FDG and raclopride study so that they can be analyzed as though they were obtained separately. (2) If additional physiologic/anatomic constraints can be imposed, further decomposition is possible. (3) For the example of raclopride, specific and nonspecific binding can be determined on a pixel-by-pixel basis. We found good agreement between the estimated GFADS factors and the simulated ground truth time activity curves (TACs), and between the GFADS factor images and the corresponding ground truth activity distributions with errors less than 7.3 ± 1.3 %. Biases in estimation of specific D2 binding and relative metabolism activity were within 5.9 ± 3.6 % compared to the ground truth values. We also evaluated our approach in simultaneous dual-isotope brain PET studies in a rhesus monkey and obtained accuracy of better than 6 % in a mid-striatal volume, for striatal activity estimation.
conclusionsDynamic image sequences acquired following near-simultaneous injection of two PET radiopharmaceuticals can be separated into components based on the differences in the kinetics, provided their kinetic behaviors are distinct.
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