ArticleInternational urology and nephrology2013
Risk factors for cognitive dysfunction in CKD and hypertensive subjects.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The effects of dialysis modality choice on cognitive functions in patients with end-stage renal failure: a systematic review and meta-analysis.International urology and nephrology · 2021Pooled it
- Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2015Pooled it
- Pooled it
- Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients.Frontiers in neuroscience · 2026Article
- Dialysis in the Elderly: A Practical Guide for the Clinician.International journal of nephrology · 2025Review
- The Role of Hypertension in Cognitive Dysfunction.Journal of clinical medicine · 2024Review
- A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodialysis in Southern Spain.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Secondary Hyperparathyroidism and Cognitive Decline.Current transplantation reports · 2023Article
- Secondary hyperparathyroidism (CKD-MBD) treatment and the risk of dementia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Prevalence of cognitive dysfunction and its risk factors in children with chronic kidney disease in a developing country.Pediatric nephrology (Berlin, Germany) · 2022Article
- Cognitive performance in dialysis patients - "when is the right time to test?"BMC nephrology · 2021Article
- Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis-A two-center study.Brain and behavior · 2020Article
- Environmental lead exposure is associated with neurocognitive dysfunction in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Arterial damage and cognitive impairment in patients with chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Arterial damage and cognitive decline in chronic kidney disease patients.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study.Scientific reports · 2018Article
- Ageing Renal Patients: We Need More Collaboration between Geriatric Services and Nephrology Departments.Healthcare (Basel, Switzerland) · 2015Review
- Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCognitive dysfunction (CO/DY) in chronic kidney disease (CKD) patients has long been recognized. Hypertension is also associated with CO/DY. The study describes associated factors with CO/DY in CKD patients compared to hypertensive subjects.
methodsNinety-six hypertensive subjects without CKD, 19 patients with CKD stages I-II, 33 with CKD III, 42 with CKD stage IV, 33 on hemodialysis (HD) and 33 on peritoneal dialysis (PD) were included in our study. Cognitive impairment measured by MMSE, clock-drawing test and IADL was considered as primary outcome.
resultsIn all groups tested, age was significantly associated with CO/DY by almost all cognitive function tests. Among CKD patients, CKD stage and DM were significantly associated with CO/DY by all three cognitive function tests. PTH levels were also associated with CO/DY by MMSE and clock-drawing tests. In hypertensives, pulse pressure (PP) was associated with CO/DY by clock-drawing and IADL tests, while those receiving CCBs as monotherapy were less likely to have CO/DY by IADL test. For dialysis patients, DM was significantly related to CO/DY by MMSE and clock-drawing tests. In the same group of patients Hb <11 g/dl was significantly correlated with CO/DY by MMSE, dialysis modality and Kt/V >1.2 by IADL test. PD patients were less likely to present with CO/DY by clock-drawing test.
conclusionsIn every CKD stage, the risk of CO/DY increased significantly. Low Hb levels (Hb <11 g/dl) and increased serum PTH levels were associated with CO/DY while DM plays also a significant role in cognitive function deterioration. Among hypertensive subjects, those with PP ≤60 mmHg or receiving CCBs showed a better executive function.
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