ArticleInternational journal of impotence research
Limited effect of testosterone treatment for erectile dysfunction caused by high-estrogen levels in rats.
Article in International journal of impotence research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications.International journal of impotence research · 2026Review
- Estrogenic endocrine disruptor exposure directly impacts erectile function.Communications biology · 2024Article
- Effect of High Testosterone Levels on Endothelial Function in Aorta and Erectile Function in Rats.Sexual medicine · 2022Article
- Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats.Sexual medicine · 2022Article
- Gosha-Jinki-Gan Improved Erectile Dysfunction Caused by Anti-Cancer Agent Oxaliplatin by Decreasing Transcriptional Expression of Phosphodiesterase-5 in Rats.Sexual medicine · 2022Article
- Influence of anticancer agents on sexual function: An in vivo study based on the US FDA Adverse Event Reporting System.Andrology · 2022Article
- Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats.Sexual medicine · 2021Article
- Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes.BMJ open diabetes research & care · 2020Article
- Effect of estradiol on penile erection: a cross-sectional study.Translational andrology and urology · 2019Article
- Aqueous extract ofFood science and biotechnology · 2019Article
- The relationship between hydration status, male sexual dysfunction and depression in hemodialysis patients.Therapeutics and clinical risk management · 2018Article
- Comparison of two cannulation methods for assessment of intracavernosal pressure in a rat model.PloS one · 2018Article
- Estradiol is an independent risk factor for organic erectile dysfunction in eugonadal young men.Asian journal of andrologyArticle
- The role of estradiol in male reproductive function.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some studies suggest that high-estrogen levels lead to erectile dysfunction (ED); high-estrogen levels are known to decrease testosterone levels. However, no study has examined whether testosterone replacement can improve the ED induced by high-estrogen levels. We investigated the effects of testosterone on ED caused by high-estrogen levels in rats. Rats were distributed in the following groups: (1) control (vehicle for 2 weeks), (2) the estrogen-treated group (ES; estradiol (3 μg kg(-1) day(-1)) for 2 weeks), and (3) the estrogen- and testosterone-treated group (ES+TE; estradiol (3 μg kg(-1) day(-1)) and testosterone (3 mg kg(-1) day(-1)) for 2 weeks). We measured smooth muscle function via isometric tension and erectile function by measuring the intracavernosal pressure on cavernous nerve stimulation. In the ES group, the contraction of the corpus cavernosum smooth muscle increased in response to noradrenalin, and its relaxation decreased in response to the nitric oxide donor, sodium nitroprusside. Further, the erectile function was significantly decreased. In the ES+TE group, neither smooth muscle function nor erectile function was significantly improved. In conclusion, a high-estrogen milieu affected erectile function in rats, and testosterone treatment did not improve the ED caused by high-estrogen levels.
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