Evidence map›Paper›PMID 23636265›Full record

ReviewPhysiology (Bethesda, Md.)2013

cAMP and mitochondria.

Federica Valsecchi, Lavoisier S Ramos-Espiritu, Jochen Buck, Lonny R Levin, Giovanni Manfredi

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
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  3. Therapeutic Promise and Biotechnological Prospects ofInternational journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
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  12. Review
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  14. Observational
  15. Article
  16. Review
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  18. Article
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  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Federica ValsecchiDepartment of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USA.
Lavoisier S Ramos-Espiritu
Jochen Buck
Lonny R Levin
Giovanni Manfredi
Cornell University · US

Funding

BICARBONATE REGULATED ADENYLYL CYCLASER01GM062328 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUCK, JOCHEN, LEVIN, LONNY R · 2001 to 2013
$4.6M
Modulation of Oxidative phosphorylation by mitochondrial soluble adenylyl cyclaseR01GM088999 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MANFREDI, GIOVANNI · 2009 to 2014
$2.1M
Soluble adenylyl cyclase isoforms essential for male fertilityR01HD059913 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUCK, JOCHEN, LEVIN, LONNY R · 2009 to 2013
$1.7M
Neuronal growth factor signaling via cAMPR01NS055255 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVIN, LONNY R · 2007 to 2010
$1.5M
NICHD NIH HHS HD-059913NICHD NIH HHS R01 HD059913NIGMS NIH HHS GM-088999NIGMS NIH HHS GM-62328NIGMS NIH HHS R01 GM062328NIGMS NIH HHS R01 GM088999NINDS NIH HHS NS-55255NINDS NIH HHS R01 NS055255
6 · The paper itself

Abstract

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

Indexed as

Second Messenger SystemsAdenylyl CyclasesAnimalsCyclic AMPCyclic AMP-Dependent Protein KinasesEnergy MetabolismHumansMitochondriaMitochondrial ProteinsPhosphorylationAdenylyl CyclasesCyclic AMPCyclic AMP-Dependent Protein KinasesMitochondrial Proteins

Identifiers

PMID23636265
PMCPMC3870303
OpenAlexW2119625955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.