ReviewNeuro-degenerative diseases2013
A hypnic hypothesis of Alzheimer's disease.
Review in Neuro-degenerative diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- The Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale in frontotemporal dementia and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Reciprocal Interaction Between Sleep and Alzheimer's Disease.Advances in experimental medicine and biology · 2021Article
- Sleep symptoms in syndromes of frontotemporal dementia and Alzheimer's disease: A proof-of-principle behavioural study.eNeurologicalSci · 2019Article
- Aberrant brain stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease.Neuropsychiatric disease and treatment · 2016Article
- Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease.Brain : a journal of neurology · 2014Article
- The sleep-wake cycle and Alzheimer's disease: what do we know?Neurodegenerative disease management · 2014Review
- Omental transplantation for neurodegenerative diseases.American journal of neurodegenerative disease · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUnderstanding the pathophysiology of Alzheimer's disease (AD) is of fundamental importance for improved diagnosis, monitoring and ultimately, treatment.
objectiveA role for the sleep-wake cycle in the pathogenesis of AD has been proposed, but remains to be worked out in detail.
methodsHere we draw together several lines of previous work to outline a 'hypnic hypothesis' of AD.
resultsWe propose that altered function of brainstem neurotransmitter pathways associated with sleep, promotes regionally specific disintegration of a cortico-subcortical 'default mode' brain network that is selectively vulnerable in AD.
conclusionThe formation of a dynamic toxic state within this vulnerable network linked to sleep-wake disruption, would in turn lead to failure of synaptic repair, increased transmission of pathogenic misfolded proteins and a self-amplifying neurodegenerative process. We consider the evidence for this hypnic hypothesis and the implications that follow on from it.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.