ArticleJournal of the Royal Society, Interface2013
Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity-An Experimental In-Vivo Study.Clinical oral implants research · 2026Article
- Layer-by-Layer Coatings of Collagen-Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections.ACS applied materials & interfaces · 2023Article
- Physical Chemistry Study of Collagen-Based Multilayer Films.Gels (Basel, Switzerland) · 2023Article
- Construction of functional surfaces for dental implants to enhance osseointegration.Frontiers in bioengineering and biotechnology · 2023Review
- Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces.International journal of molecular sciences · 2022Article
- De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds.Bioactive materials · 2022Article
- Tailored Polyelectrolyte Multilayer Systems by Variation of Polyelectrolyte Composition and EDC/NHS Cross-Linking: Physicochemical Characterization and In Vitro Evaluation.Nanomaterials (Basel, Switzerland) · 2022Article
- A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections.Materials today. Bio · 2022Article
- Fabrication of gentamicin loaded Col-I/HA multilayers modified titanium coatings for prevention of implant infection.Frontiers in chemistry · 2022Article
- Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface.World journal of stem cells · 2020Review
- Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces.RSC advances · 2018Article
- An in vivo study on the effect of coating stability on osteointegration performance of collagen/hyaluronic acid multilayer modified titanium implants.Bioactive materials · 2018Article
- The effect of different collagen modifications for titanium and titanium nitrite surfaces on functions of gingival fibroblasts.Clinical oral investigations · 2017Article
- Covalently immobilised type I collagen facilitates osteoconduction and osseointegration of titanium coated implants.Journal of orthopaedic translation · 2016Article
- Collagen self-assembly on orthopedic magnesium biomaterials surface and subsequent bone cell attachment.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Layer-by-layer (LBL) self-assembly technique has been proved to be a highly effective method to immobilize the main components of the extracellular matrix such as collagen and hyaluronic acid on titanium-based implants and form a polyelectrolyte multilayer (PEM) film by electrostatic interaction. However, the formed PEM film is unstable in the physiological environment and affects the long-time effectiveness of PEM film. In this study, a modified LBL technology has been developed to fabricate a stable collagen/hyaluronic acid (Col/HA) PEM film on titanium coating (TC) by introducing covalent immobilization. Scanning electron microscopy, diffuse reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize the PEM film. Results of Sirius red staining demonstrated that the chemical stability of PEM film was greatly improved by covalent cross-linking. Cell culture assays further illustrated that the functions of human mesenchymal stem cells, such as attachment, spreading, proliferation and differentiation, were obviously enhanced by the covalently immobilized Col/HA PEM on TCs compared with the absorbed Col/HA PEM. The improved stability and biological properties of the Col/HA PEM covalently immobilized TC may be beneficial to the early osseointegration of the implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.