ArticleAnalytical chemistry2013
Multiplexed electrochemical protein detection and translation to personalized cancer diagnostics.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Review and Analysis of Electrochemical Instrumentation Design for Continuous Multi-Analyte Microfluidic Sensor Arrays.Sensors (Basel, Switzerland) · 2026Review
- DNA-Assisted CRISPR-Cas12a Enhanced Fluorescent Assay for Protein Detection in Complicated Matrices.ACS applied bio materials · 2025Article
- Metal-organic framework-interfaced ELISA probe enables ultrasensitive detection of extracellular vesicle biomarkers.Journal of materials chemistry. B · 2024Article
- REASSURED Multiplex Diagnostics: A Critical Review and Forecast.Biosensors · 2022Review
- Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices.Nature protocols · 2021Article
- Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray.Biosensors & bioelectronics · 2021Article
- Review
- Sub-zeptomole Detection of Biomarker Proteins Using a Microfluidic Immunoarray with Nanostructured Sensors.Analytical chemistry · 2020Article
- Translating in vitro diagnostics from centralized laboratories to point-of-care locations using commercially-available handheld meters.Trends in analytical chemistry : TRAC · 2020Article
- Article
- Glucose biosensor based on open-source wireless microfluidic potentiostat.Sensors and actuators. B, Chemical · 2019Article
- Multiplexed Electrochemical Cancer Diagnostics With Automated Microfluidics.Electroanalysis · 2019Article
- Multiplexed Instrument-Free Bar-Chart SpinChip Integrated with Nanoparticle-Mediated Magnetic Aptasensors for Visual Quantitative Detection of Multiple Pathogens.Analytical chemistry · 2018Article
- Automated 3D-Printed Microfluidic Array for Rapid Nanomaterial-Enhanced Detection of Multiple Proteins.Analytical chemistry · 2018Article
- Multiplexed Point-of-Care Testing - xPOCT.Trends in biotechnology · 2017Review
- FeBiosensors & bioelectronics · 2017Article
- Multiplexed Electrochemical Immunosensors for Clinical Biomarkers.Sensors (Basel, Switzerland) · 2017Review
- An electrochemical method for sensitive and rapid detection of FAM134B protein in colon cancer samples.Scientific reports · 2017Article
- Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development.Methods (San Diego, Calif.) · 2017Review
- Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins.Lab on a chip · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Measuring diagnostic panels of multiple proteins promises a new, personalized approach to early detection and therapy of diseases like cancer. Levels of biomarker proteins in patient serum can provide a continually updated record of disease status. Research in electrochemical detection of proteins has produced exquisitely sensitive approaches. Most utilize ELISA-like sandwich immunoassays incorporating various aspects of nanotechnology. Several of these ultrasensitive methodologies have been extended to microfluidic multiplexed protein detection, but engineered solutions are needed to measure more proteins in a single device from a small patient sample such as a drop of blood or tissue lysate. To achieve clinical or point-of-care (POC) use, simplicity and low cost are essential. In multiplexed microfluidic immunoassays, required reagent additions and washing steps pose a significant problem calling for creative engineering. A grand challenge is to develop a general cancer screening device to accurately measure 50-100 proteins in a simple, cost-effective fashion. This will require creative solutions to simplified reagent addition and multiplexing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.