ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
Plasma cell neoplasms in US solid organ transplant recipients.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Post-Transplant Lymphoproliferative Disorder following Heart Transplantation Presenting as a Retroperitoneal Plasmacytoma: A Case Report and Review of the Literature.Acta haematologica · 2026Review
- Non-DLBCL monomorphic and Hodgkin lymphoma PTLD: clinical insights and treatment strategies.Blood advances · 2025Review
- The Prevalence of Epstein-Barr Virus in Plasma Cell Neoplasms is Higher in HIV-Positive Individuals.International journal of surgical pathology · 2023Article
- FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.Cell communication and signaling : CCS · 2023Article
- Anaplastic plasmacytoma: a rare tumor presenting as a pathological fracture in a younger adult.Skeletal radiology · 2018Article
- Autologous stem cell transplantation in EBV-positive post-renal transplant refractory multiple myeloma: A case report and literature review.Oncology letters · 2018Article
- Cancer Risk After Pediatric Solid Organ Transplantation.Pediatrics · 2017Article
- HIV Infection, Immunosuppression, and Age at Diagnosis of Non-AIDS-Defining Cancers.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms: 2015 SH/EAHP Workshop Report-Part 3.American journal of clinical pathology · 2017Article
- Plasma cell neoplasia after kidney transplantation: French cohort series and review of the literature.PloS one · 2017Review
- Survival Analyses and Prognosis of Plasma-Cell Myeloma and Plasmacytoma-Like Posttransplantation Lymphoproliferative Disorders.Clinical lymphoma, myeloma & leukemia · 2016Article
- HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation.Transplantation · 2016Article
- Successful treatment with lenalidomide of secondary multiple myeloma with extramedullary liver plasmacytoma in a renal transplant recipient: A case report and review of the literature.Oncology letters · 2015Article
- [Multiple myeloma post renal transplant: one case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Review
- Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States.American journal of hematology · 2014Article
- HIV, EBV, and monoclonal gammopathy.Blood · 2013Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Transplant recipients have elevated risk for plasma cell neoplasms (PCNs, comprising multiple myeloma and plasmacytoma), but little is known about risk factors in the transplant setting. Through linkage of the US solid organ transplant registry with 15 state/regional cancer registries, we identified 140 PCNs in 202 600 recipients (1987-2009). PCN risk was 1.8-fold increased relative to the general population (standardized incidence ratio [SIR] 1.80, 95%CI 1.51-2.12). Among cases, 102 were multiple myeloma (SIR 1.41) and 38 were plasmacytoma (SIR 7.06). PCN incidence increased with age, but due to the rarity of PCNs in younger people in the general population, SIRs were highest in younger transplant recipients (p = 0.03). PCN risk was especially high in recipients who were Epstein-Barr virus (EBV) seronegative at transplantation (SIR 3.93). EBV status was known for 18 tumors, of which 7 (39%) were EBV positive. Following liver transplantation, PCN risk was higher in recipients with cholestatic liver disease (SIR 2.78); five of these cases had primary biliary cirrhosis (PBC). A role for primary EBV infection after transplantation is supported by the increased PCN risk in young EBV seronegative recipients and the presence of EBV in tumors. PBC may be another risk factor, perhaps by causing chronic immune activation.
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