ReviewCritical care (London, England)2013
The potential harm of oxygen therapy in medical emergencies.
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04079465 (Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia), which is not on this map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia
Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2014Pooled it
- Impact of Oxygen Targets on Sepsis Outcome: A Randomized Controlled Trial.Shock (Augusta, Ga.) · 2026Trial
- Refining oxygen management through rigorous Oxygen Reserve Index (ORi) monitoring in patients undergoing general anesthesia: a randomized controlled trial : ORi to avoid excessive hyperoxia.Journal of clinical monitoring and computing · 2025Trial
- Automated oxygen administration versus manual control in acute cardiovascular care: a randomised controlled trial.Heart (British Cardiac Society) · 2024Trial
- Effects of intraoperative inspired oxygen fraction (FiOCritical care (London, England) · 2023Trial
- Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial.Critical care (London, England) · 2022Trial
- Trial
- Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome.Critical care medicine · 2018Trial
- Electrical Impedance Tomography-guided PEEP Titration in Patients Undergoing Laparoscopic Abdominal Surgery.Medicine · 2016Trial
- Moderate hyperoxic versus near-physiological oxygen targets during and after coronary artery bypass surgery: a randomised controlled trial.Critical care (London, England) · 2016Trial
- Peripheral Oxygen Saturation Targets and Hyperoxemia in Critical Care: Influence of pH, FAntioxidants (Basel, Switzerland) · 2026Article
- Beyond preservation: future machine perfusion for liver assessment and repair.Nature reviews. Gastroenterology & hepatology · 2025Review
- Effects of low-intensity blood flow restriction training on myocardial injury indices, antioxidant and anti-apoptotic capacity in rats.Frontiers in physiology · 2025Article
- An exploration of healthcare professionals' knowledge and perceived barriers about acute oxygen therapy: a survey in a tertiary care hospital, Sudan.BMC medical education · 2024Article
- The physiological basis for individualized oxygenation targets in critically ill patients with circulatory shock.Intensive care medicine experimental · 2024Review
- Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.Neurocritical care · 2024Observational
- Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration.Frontiers in bioengineering and biotechnology · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In medical emergencies, supplemental oxygen is often administrated routinely. Most paramedics and physicians believe that high concentrations of oxygen are life-saving 1. Over the last century, however, a plethora of studies point to possible detrimental effects of hyperoxia induced by supplemental oxygen in a variety of medical emergencies. This viewpoint provides a historical overview and questions the safety of routine high-dose oxygen administration and is based on pathophysiology and (pre)clinical findings in various medical emergencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.