Evidence map›Paper›PMID 23634971›Full record

ArticleMobile DNA2013

Now on display: a gallery of group II intron structures at different stages of catalysis.

Marco Marcia, Srinivas Somarowthu, Anna Marie Pyle

Abstract read
In one paragraph

Article in Mobile DNA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Controlled dynamic remodeling of the spliceosome active site enables the first step of splicing.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. The ChloroplastCells · 2021
    Review
  6. The Mitogenomes ofFrontiers in microbiology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Contribution of Mobile Group II Introns toFrontiers in microbiology · 2018
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marco MarciaDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. marco.marcia@yale.edu.
Srinivas Somarowthu
Anna Marie Pyle

Funding

STUCTURE AND FUNCTION OF GROUP II INTRONSR01GM050313 · NIGMS · YALE UNIVERSITY · PI PYLE, ANNA MARIE · 1994 to 2016
$4.6M
NIGMS NIH HHS R01 GM050313
6 · The paper itself

Abstract

Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed.

Identifiers

PMID23634971
PMCPMC3669008

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.