ArticleGenes & cancer2012
Decoding ubiquitin for mitosis.
Article in Genes & cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.Scientific reports · 2022Article
- Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1.Molecules (Basel, Switzerland) · 2022Article
- Non-proteolytic ubiquitylation in cellular signaling and human disease.Communications biology · 2022Review
- The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression.International journal of molecular sciences · 2021Review
- USP13 controls the stability of Aurora B impacting progression through the cell cycle.Oncogene · 2020Article
- Molecular cloning, expression, overproduction and characterization of human TRAIP Leucine zipper protein.Saudi journal of biological sciences · 2020Article
- Deubiquitinating Enzymes: A Critical Regulator of Mitosis.International journal of molecular sciences · 2019Review
- Review
- The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity.Oncogene · 2018Article
- Regulation of the cell cycle and centrosome biology by deubiquitylases.Biochemical Society transactions · 2017Review
- USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.Oncotarget · 2016Article
- Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.Developmental cell · 2016Article
- The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.The Journal of cell biology · 2015Article
- Using in vivo biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.Molecular & cellular proteomics : MCP · 2014Article
- The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conjugation of ubiquitin (ubiquitination) to substrate proteins is a widespread modification that ensures fidelity of many cellular processes. During mitosis, different dynamic morphological transitions have to be coordinated in a temporal and spatial manner to allow for precise partitioning of the genetic material into two daughter cells, and ubiquitination of key mitotic factors is believed to provide both directionality and fidelity to this process. While directionality can be achieved by a proteolytic type of ubiquitination signal, the fidelity is often determined by various types of ubiquitin conjugation that does not target substrates for proteolysis by the proteasome. An additional level of complexity is provided by various ubiquitin-interacting proteins that act downstream of the ubiquitinated substrate and can serve as "decoders" for the ubiquitin signal. They may, specifically reverse ubiquitin attachment (deubiquitinating enzymes, DUBs) or, act as a receptor for transfer of the ubiquitinated substrate toward downstream signaling components and/or subcellular compartments (ubiquitin-binding proteins, UBPs). In this review, we aim at summarizing the knowledge and emerging concepts about the role of ubiquitin decoders, DUBs, and UBPs that contribute to faithful regulation of mitotic division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.