ArticleAmerican journal of translational research2013
Invasive catheterization of the hepatic artery for preclinical investigation of liver-directed therapies in rodent models of liver cancer.
Article in American journal of translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
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- Sorafenib plus memory-like natural killer cell immunochemotherapy boosts treatment response in liver cancer.BMC cancer · 2024Article
- MRI radiomics to monitor therapeutic outcome of sorafenib plus IHA transcatheter NK cell combination therapy in hepatocellular carcinoma.Journal of translational medicine · 2024Article
- Sorafenib plus memory like natural killer cell combination therapy in hepatocellular carcinoma.American journal of cancer research · 2024Article
- Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection.International journal of nanomedicine · 2023Article
- Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats.Frontiers in oncology · 2022Article
- Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of Hepatocellular Carcinoma.Radiology. Imaging cancer · 2021Article
- Treatment margins in radiotherapy for liver tumors visualized as T2*-hypointense areas on SPIO-enhanced MRI at 9.4 T.Magma (New York, N.Y.) · 2020Article
- An implanted port-catheter system for repeated hepatic arterial infusion of low-density lipoprotein-docosahexaenoic acid nanoparticles in normal rats: A safety study.Toxicology and applied pharmacology · 2020Article
- Factors impacting technical success rate of image-guided intra-arterial therapy in rat orthotopic liver tumor model.American journal of translational research · 2019Article
- Vascular Interventional Radiology-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis with Theranostic Gold Nanorods.ACS nano · 2018Article
- MRI-guided interventional natural killer cell delivery for liver tumor treatment.Cancer medicine · 2018Article
- Acidic pH-Triggered Drug-Eluting Nanocomposites for Magnetic Resonance Imaging-Monitored Intra-arterial Drug Delivery to Hepatocellular Carcinoma.ACS applied materials & interfaces · 2016Article
- Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.Experimental and molecular pathology · 2014Review
- Poly(lactide-co-glycolide) microspheres for MRI-monitored transcatheter delivery of sorafenib to liver tumors.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study demonstrated invasive and reproducible hepatic artery catheterization in rats. A rigorously documented guide and pictorial essay describes the performance of an invasive hepatic artery catheterization technique suitable for the study of liver-targeted interventional procedures in rodent models of liver cancer. The goal was to produce a well-illustrated guide to hepatic artery catheterization under direct visualization via the gastroduodenal artery (GDA). MATERIALS AND
methods20 Sprague Dawley rats were inoculated with McA-RH7777 HCC cells in the left lateral liver lobe. Magnetic resonance imaging (MRI) was used to measure tumor growth. Catheter placement in the hepatic artery proper was performed by entry through the GDA under direct visualization after laparotomy. Digital subtraction angiography confirmed catheter placement in the hepatic artery proper. Antegrade blood flow to the liver was restored after catheter removal. Rats were euthanized after procedures; livers were harvested for hematoxylin and eosin (H&E) staining.
results85.0% of inoculated animals developed measurable tumors on MRI; average tumor size was 6.3 ± 2.3 mm × 4.3 ± 1.5 mm (mean ± SD). 94.1% of animals with tumors were successfully catheterized. H&E staining demonstrated tumor growth in all inoculated animals, including those with no measurable tumors on MRI.
conclusionInvasive catheter placement in the hepatic artery of a rodent model of HCC can be performed reproducibly according to the techniques described in this tutorial. These catheterization techniques are ideal for a broad range of preclinical IR studies intending to evaluate the efficacy of intra-arterial therapies for the treatment of primary and metastatic liver tumors.
Indexed as
Identifiers
23634238PMC3633970W2200274876What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.